Zika vaccine development-current progress and challenges for the future

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20 Scopus citations


Zika virus is an emergent pathogen that gained significant importance during the epidemic in South and Central America as unusual and alarming complications of infection were recognized. Although initially considered a self-limited benign infection, a panoply of neurologic complications were recognized including a Guillain-Barré-like syndrome and in-utero fetal infection causing microcephaly, blindness, and other congenital neurologic complications. Numerous Zika virus vaccines were developed, with nine different vaccines representing five different platforms entered into clinical trials, one progressing to Phase II. Here we review the current landscape and challenges confronting Zika virus vaccine development.

Original languageEnglish (US)
Article number104
JournalTropical Medicine and Infectious Disease
Issue number3
StatePublished - Jul 14 2019


  • Emerging infectious disease
  • Flavivirus
  • Sample size
  • Vaccine
  • Zika virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Immunology and Microbiology(all)


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