Zero-mode waveguides for single molecule analysis and fast DNA sequencing

Michael Levene, Jonas Korlach, Stephen Turner, Harold G. Craighead, Watt W. Webb

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Zero-mode waveguides for single molecule analysis and fast DNA sequencing were presented. Arrays of zero-mode waveguides which consisted of subwavelengths holes in thin metal films on fused silica coverslips were manufactured using electron-beam lithography. A finite-element model of intensity distribution within such waveguides was used to predict the effective observation volume in the waveguides. The effectiveness of zero-mode waveguides was demonstrated by real-time observation of single molecules of DNA polymerase immobilized inside waveguides.

Original languageEnglish
Title of host publicationPacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest
StatePublished - Jan 1 2002
EventConference on Lasers and Electro-Optics (CLEO 2002) - Long Beach, CA, United States
Duration: May 19 2002May 24 2002

Other

OtherConference on Lasers and Electro-Optics (CLEO 2002)
CountryUnited States
CityLong Beach, CA
Period5/19/025/24/02

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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