Abstract
Zero-mode waveguides for single molecule analysis and fast DNA sequencing were presented. Arrays of zero-mode waveguides which consisted of subwavelengths holes in thin metal films on fused silica coverslips were manufactured using electron-beam lithography. A finite-element model of intensity distribution within such waveguides was used to predict the effective observation volume in the waveguides. The effectiveness of zero-mode waveguides was demonstrated by real-time observation of single molecules of DNA polymerase immobilized inside waveguides.
Original language | English |
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Title of host publication | Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest |
State | Published - Jan 1 2002 |
Event | Conference on Lasers and Electro-Optics (CLEO 2002) - Long Beach, CA, United States Duration: May 19 2002 → May 24 2002 |
Other
Other | Conference on Lasers and Electro-Optics (CLEO 2002) |
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Country/Territory | United States |
City | Long Beach, CA |
Period | 5/19/02 → 5/24/02 |
ASJC Scopus subject areas
- Physics and Astronomy(all)