@inproceedings{5b76fa851f5f429f914f6c4cd9909026,
title = "Zebrafish xenograft breast cancer models for high-throughput drug response screening",
abstract = "The heterogeneity and dynamic nature of cancerous tumors, such as those seen in breast cancer, pose a unique challenge in determining treatment regimens. The use of zebrafish as an in vivo model of breast cancer provides a high-throughput model with the potential to screen for efficacious drugs on a patient-by-patient basis. In this study, we use two-photon microscopy to measure metabolic changes in zebrafish with xenografted breast cancer tumors before, during, and after treatment with the anti-cancer drug paclitaxel. We use this metabolic imaging data to evaluate the zebrafish as a robust in vivo model of breast cancer. Preliminary results suggest the xenograft tumors respond to treatment with paclitaxel at 48 hours post treatment, as demonstrated by significant changes in NAD(P)H fluorescence lifetimes.",
keywords = "FAD, Multiphoton microscopy, NAD(P)H, breast cancer, drug screen-ing, uorescence lifetime imaging",
author = "Rebecca Schmitz and Walsh, {Alex J.} and Kelsey Tweed and Steve Trier and Anna Huttenlocher and Skala, {Melissa C.}",
note = "Funding Information: The authors would like to thank Julie Rindy for assistance with zebrafish proceedures. by the NIH R01 CA185747. Publisher Copyright: {\textcopyright} 2019 SPIE. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.; Biophysics, Biology and Biophotonics IV 2019: The Crossroads ; Conference date: 02-02-2019",
year = "2019",
doi = "10.1117/12.2513688",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Adam Wax and Vadim Backman",
booktitle = "Biophysics, Biology and Biophotonics IV",
address = "United States",
}