Abstract

Leber hereditary optic neuropathy (LHON) produces a subacute and typically bilateral but sequential optic neuropathy. LHON is a mitochondrial disease and the most common mutations are at positions 11778, 14484 and 3460. LHON typically presents in young (age 20-40), healthy men but may occur in either sex and at any age. We report a case of LHON in a 72-year-old man and we emphasize the importance of testing for LHON in all cases of unexplained bilateral and sequential optic neuropathy with a ceco-central or central scotoma.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalSurvey of Ophthalmology
Volume53
Issue number4
DOIs
StatePublished - Jan 1 2008

Keywords

  • central scotoma
  • Leber hereditary optic neuropathy

ASJC Scopus subject areas

  • Ophthalmology

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