Young Little mice express a premature cardiovascular aging phenotype

Anilkumar K. Reddy, Craig J. Hartley, Thuy T. Pham, Gretchen Darlington, Mark L. Entman, George Taffet

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


To investigate the effect of growth hormone and insulin-like growth factor 1 deficiency on the aging mouse arterial system, we compared the hemodynamics in young (4 months) and old (30 months) growth hormone-releasing hormone receptor null dwarf (Little) mice and their wild-type littermates. Young Little mice had significantly lower peak and mean aortic velocity and significantly higher aortic impedance than young wild-type mice. However, unlike the wild-type mice, there were no significant changes in arterial function with age in the Little mice. Aortic pulse wave velocity estimated using characteristic impedance increased with age in the wild-type mice, but it changed minimally in the Little mouse. We therefore conclude that arterial function in Little mice expresses a premature aging phenotype at young age and may neither enhance nor reduce their longevity.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume69 A
Issue number2
StatePublished - 2014


  • Aortic impedance
  • Cardiovascular function
  • GH/IGF-1 deficiency
  • Longevity
  • Pulse wave velocity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)


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