Abstract
To investigate the effect of growth hormone and insulin-like growth factor 1 deficiency on the aging mouse arterial system, we compared the hemodynamics in young (4 months) and old (30 months) growth hormone-releasing hormone receptor null dwarf (Little) mice and their wild-type littermates. Young Little mice had significantly lower peak and mean aortic velocity and significantly higher aortic impedance than young wild-type mice. However, unlike the wild-type mice, there were no significant changes in arterial function with age in the Little mice. Aortic pulse wave velocity estimated using characteristic impedance increased with age in the wild-type mice, but it changed minimally in the Little mouse. We therefore conclude that arterial function in Little mice expresses a premature aging phenotype at young age and may neither enhance nor reduce their longevity.
Original language | English (US) |
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Pages (from-to) | 152-159 |
Number of pages | 8 |
Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
Volume | 69 A |
Issue number | 2 |
DOIs | |
State | Published - 2014 |
Keywords
- Aortic impedance
- Cardiovascular function
- GH/IGF-1 deficiency
- Longevity
- Pulse wave velocity
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
- General Medicine