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YAP1 inhibitors and methods of treating a subject with a cancer that include administering a YAP1 inhibitor are disclosed. Also disclosed are methods for determining responsiveness to a YAP1 inhibitor in a subject, methods for diagnosing a tumor in a subject including determining the level of YAP1 expression, compositions that include YAP1 inhibitors, and methods of using those compositions.
Original languageEnglish (US)
Patent numberWO 2017/197104 Al
IPCA61K 31/409 (2006.01) C07D 487/22 (2006.01)
Priority date5/11/16
Filing date5/11/17
StateSubmitted - Nov 16 2017


  • YAP1
  • cancer

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