xl21: A localized maternal transcript in Xenopus laevis

Malgorzata Kloc, Bramham A. Reddy, Mill Miller, Eric Eastman, Laurence D. Etkin

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We describe the cloning and characterization of a partial cDNA, xl21, that represents an RNA, which is localized in the animal hemisphere of Xenopus oocytes. This RNA is also detected in an animal to vegetal gradient during early cleavage stages. The xl21 RNA titer decreases from fertilization through the gastrula stage, after which it is not detectable on northern blots. The amino acid composition of the xl21 conceptual protein derived from cDNA sequencing reveals a large number of acidic residues similar in distribution to proteins that function as transcriptional activators.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
JournalMolecular Reproduction and Development
Issue number4
StatePublished - Apr 1991


  • Development
  • Differentiation
  • Localized RNA
  • Maternal gene

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology


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