xl21: A localized maternal transcript in Xenopus laevis

Malgorzata Kloc; Bramham A. Reddy; Mill Miller; Eric Eastman; Laurence D. Etkin

doi:10.1002/mrd.1080280405

xl21: A localized maternal transcript in Xenopus laevis

Malgorzata Kloc, Bramham A. Reddy, Mill Miller, Eric Eastman, Laurence D. Etkin

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12 Scopus citations

Abstract

We describe the cloning and characterization of a partial cDNA, xl21, that represents an RNA, which is localized in the animal hemisphere of Xenopus oocytes. This RNA is also detected in an animal to vegetal gradient during early cleavage stages. The xl21 RNA titer decreases from fertilization through the gastrula stage, after which it is not detectable on northern blots. The amino acid composition of the xl21 conceptual protein derived from cDNA sequencing reveals a large number of acidic residues similar in distribution to proteins that function as transcriptional activators.

Original language	English (US)
Pages (from-to)	341-345
Number of pages	5
Journal	Molecular Reproduction and Development
Volume	28
Issue number	4
DOIs	https://doi.org/10.1002/mrd.1080280405
State	Published - Apr 1991

Keywords

Development
Differentiation
Localized RNA
Maternal gene

ASJC Scopus subject areas

Genetics
Developmental Biology
Cell Biology

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10.1002/mrd.1080280405

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AU - Kloc, Malgorzata

AU - Reddy, Bramham A.

AU - Miller, Mill

AU - Eastman, Eric

AU - Etkin, Laurence D.

PY - 1991/4

Y1 - 1991/4

N2 - We describe the cloning and characterization of a partial cDNA, xl21, that represents an RNA, which is localized in the animal hemisphere of Xenopus oocytes. This RNA is also detected in an animal to vegetal gradient during early cleavage stages. The xl21 RNA titer decreases from fertilization through the gastrula stage, after which it is not detectable on northern blots. The amino acid composition of the xl21 conceptual protein derived from cDNA sequencing reveals a large number of acidic residues similar in distribution to proteins that function as transcriptional activators.

AB - We describe the cloning and characterization of a partial cDNA, xl21, that represents an RNA, which is localized in the animal hemisphere of Xenopus oocytes. This RNA is also detected in an animal to vegetal gradient during early cleavage stages. The xl21 RNA titer decreases from fertilization through the gastrula stage, after which it is not detectable on northern blots. The amino acid composition of the xl21 conceptual protein derived from cDNA sequencing reveals a large number of acidic residues similar in distribution to proteins that function as transcriptional activators.

KW - Development

KW - Differentiation

KW - Localized RNA

KW - Maternal gene

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xl21: A localized maternal transcript in Xenopus laevis

Abstract

Keywords

ASJC Scopus subject areas

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