Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease: What is typical?

M. F. Weiner; W. H. Wighton-Benn; R. Risser; D. Svetlik; R. Tintner; J. Hom; R. N. Rosenberg; F. J. Bonte

doi:10.1176/jnp.5.4.415

Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease: What is typical?

M. F. Weiner, W. H. Wighton-Benn, R. Risser, D. Svetlik, R. Tintner, J. Hom, R. N. Rosenberg, F. J. Bonte

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Abstract

A study of 76 consecutive xenon-133 SPECT studies of regional cerebral blood flow was undertaken to determine the frequency of various patterns of blood flow in cases of clinically diagnosed probable and possible Alzheimer's disease. The reference tomographic section was a slice 6 cm above and parallel to the canthomeatal line. With the use of this technique, the 'classic' finding of bilateral temporoparietal (TP) flow reductions as the sole abnormality occurred in only 28% of cases. Bilateral TP reductions accompanied by bilateral or unilateral frontal flow reductions were nearly as common (24%), and other patterns accounted for the other 48% of cases.

Original language	English (US)
Pages (from-to)	415-418
Number of pages	4
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	5
Issue number	4
DOIs	https://doi.org/10.1176/jnp.5.4.415
State	Published - 1993

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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title = "Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease: What is typical?",

abstract = "A study of 76 consecutive xenon-133 SPECT studies of regional cerebral blood flow was undertaken to determine the frequency of various patterns of blood flow in cases of clinically diagnosed probable and possible Alzheimer's disease. The reference tomographic section was a slice 6 cm above and parallel to the canthomeatal line. With the use of this technique, the 'classic' finding of bilateral temporoparietal (TP) flow reductions as the sole abnormality occurred in only 28% of cases. Bilateral TP reductions accompanied by bilateral or unilateral frontal flow reductions were nearly as common (24%), and other patterns accounted for the other 48% of cases.",

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T1 - Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease

T2 - What is typical?

AU - Weiner, M. F.

AU - Wighton-Benn, W. H.

AU - Risser, R.

AU - Svetlik, D.

AU - Tintner, R.

AU - Hom, J.

AU - Rosenberg, R. N.

AU - Bonte, F. J.

PY - 1993

Y1 - 1993

N2 - A study of 76 consecutive xenon-133 SPECT studies of regional cerebral blood flow was undertaken to determine the frequency of various patterns of blood flow in cases of clinically diagnosed probable and possible Alzheimer's disease. The reference tomographic section was a slice 6 cm above and parallel to the canthomeatal line. With the use of this technique, the 'classic' finding of bilateral temporoparietal (TP) flow reductions as the sole abnormality occurred in only 28% of cases. Bilateral TP reductions accompanied by bilateral or unilateral frontal flow reductions were nearly as common (24%), and other patterns accounted for the other 48% of cases.

AB - A study of 76 consecutive xenon-133 SPECT studies of regional cerebral blood flow was undertaken to determine the frequency of various patterns of blood flow in cases of clinically diagnosed probable and possible Alzheimer's disease. The reference tomographic section was a slice 6 cm above and parallel to the canthomeatal line. With the use of this technique, the 'classic' finding of bilateral temporoparietal (TP) flow reductions as the sole abnormality occurred in only 28% of cases. Bilateral TP reductions accompanied by bilateral or unilateral frontal flow reductions were nearly as common (24%), and other patterns accounted for the other 48% of cases.

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Xenon-133 SPECT-determined regional cerebral blood flow in Alzheimer's disease: What is typical?

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