Will neurotrophic agents be harmful in Alzheimer's disease?

Stanley H. Appel, James L. McManaman, Warren J. Strittmatter

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The thesis that neurotrophic therapy in Alzheimer's disease may exacerbate the pathological state merits careful experimental verification. We are concerned about prematurely dismissing an important avenue of potential therapy which would provide a trophic stimulus to compensate for enhanced proteolysis and the deposition of A4 amyloid peptide.

Original languageEnglish (US)
Pages (from-to)580-581
Number of pages2
JournalNeurobiology of Aging
Issue number5
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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