Widespread increased expression of the DNA repair enzyme PARP in brain in ALS

S. H. Kim, J. I. Engelhardt, J. S. Henkel, L. Siklós, J. Soós, C. Goodman, Stanley H. Appel

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Expression of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) is a known response to oxidative damage of DNA. In ALS brain, PARP expression by western analyses was increased in the motor cortex, parietal cortex, and cerebellum. PARP immunostaining in the motor cortex was increased in ALS neurons and subcortical glia and macrophages. Importantly, there was widespread increased PARP expression in neurons in the parietal cortex and cerebellum, regions that are typically clinically unaffected in ALS, suggesting widespread oxidative stress.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalNeurology
Volume62
Issue number2
DOIs
StatePublished - Jan 27 2004

ASJC Scopus subject areas

  • Clinical Neurology

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