Who killed the worm and other fungal pathogenesis insights

Research output: Contribution to journalReview articlepeer-review


• The multi-host pathogenesis system entails using divergent hosts to study microbial pathogenesis. • Caenorhabditis elegans is being used to study established and to identify novel virulence determinants among many bacterial and fungal pathogens. • Fungi kill nematodes in many different ways - for example, Candida species adhere to nematode intestine, dissolve nematode tissues, and break through nematode cuticles by forming impressive networks of filaments; Drechmeria coniospora spores cause a localized infection by attaching to parts of the cuticle, and Cryptococcus neoformans (as well as Candida albicans on solid media) kill nematodes after being ingested without forming filaments. • C. elegans innate immunity pathways are involved in responding to fungi with some degree of specificity.

Original languageEnglish (US)
Pages (from-to)600-606
Number of pages7
Issue number12
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Microbiology


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