TY - JOUR
T1 - Who killed the worm and other fungal pathogenesis insights
AU - Mylonakis, Eleftherios
PY - 2007/12
Y1 - 2007/12
N2 - • The multi-host pathogenesis system entails using divergent hosts to study microbial pathogenesis. • Caenorhabditis elegans is being used to study established and to identify novel virulence determinants among many bacterial and fungal pathogens. • Fungi kill nematodes in many different ways - for example, Candida species adhere to nematode intestine, dissolve nematode tissues, and break through nematode cuticles by forming impressive networks of filaments; Drechmeria coniospora spores cause a localized infection by attaching to parts of the cuticle, and Cryptococcus neoformans (as well as Candida albicans on solid media) kill nematodes after being ingested without forming filaments. • C. elegans innate immunity pathways are involved in responding to fungi with some degree of specificity.
AB - • The multi-host pathogenesis system entails using divergent hosts to study microbial pathogenesis. • Caenorhabditis elegans is being used to study established and to identify novel virulence determinants among many bacterial and fungal pathogens. • Fungi kill nematodes in many different ways - for example, Candida species adhere to nematode intestine, dissolve nematode tissues, and break through nematode cuticles by forming impressive networks of filaments; Drechmeria coniospora spores cause a localized infection by attaching to parts of the cuticle, and Cryptococcus neoformans (as well as Candida albicans on solid media) kill nematodes after being ingested without forming filaments. • C. elegans innate immunity pathways are involved in responding to fungi with some degree of specificity.
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U2 - 10.1128/microbe.2.600.1
DO - 10.1128/microbe.2.600.1
M3 - Review article
AN - SCOPUS:37349101935
VL - 2
SP - 600
EP - 606
JO - Microbe
JF - Microbe
SN - 1558-7452
IS - 12
ER -