A 51-year-old man with rheumatoid arthritis and diabetes mellitus presented with new onset left-sided hemiparesis, left-sided neglect, and left-sided incongruous, denser inferiorly, homonymous hemianopsia. Magnetic resonance image of the brain showed prominent swelling of the right frontal, parietal, and occipital lobes greater than on the left with significant change in the fluid-attenuated inversion recovery signal in the gray matter. Perinuclear antineutrophil cytoplasmic antibodies titers were elevated, and skin biopsy demonstrating leukocytoclastic vasculitis. He showed marked clinical and radiographic improvement in association with recovery of vascular abnormalities after the initiation of prednisone, pulse therapy with methylprednisolone, and methotrexate. Clinicians should be aware of the possibility of neuro-ophthalmic manifestations of rheumatoid arthritis, including rheumatoid arthritis-related vasculitis causing homonymous hemianopsia.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalSurvey of Ophthalmology
Issue number1
StatePublished - Jan 1 2016


  • Autoimmune disease
  • Cerebral vasculitis
  • Homonymous hemianopsia
  • P-ANCA antibodies
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Ophthalmology


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