TY - JOUR
T1 - What Is the Role of the Inflammation in the Pathogenesis of Heart Failure?
AU - Castillo, Elena C.
AU - Vázquez-Garza, Eduardo
AU - Yee-Trejo, David
AU - García-Rivas, Gerardo
AU - Torre-Amione, Guillermo
N1 - Funding Information:
This work was partially supported by the GIEE Medicina Cardiovascular y Metabolomica (Tecnologico de Monterrey, 0020209M01) as well as the CONACYT Grants 151136, 133591, 269399, Fronteras de la Ciencia Grant (0682).
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Purpose of Review: In heart failure, whether it is associated with reduced or preserved ejection fraction, the immune system is activated and contributes to heart remodeling and impaired function. Recent Findings: Studies indicate that cells of the immune system not only play a role in the pathology but are also critical regulators of heart function. Knowledge about the role of the immune system driving heart failure will lead to the development of new targets to this system, particularly in those patients that, despite the apparent wellness, relapse and worsen. Summary: In this review, we will address the diverse mechanisms that trigger inflammation and their impact on heart failure progression.
AB - Purpose of Review: In heart failure, whether it is associated with reduced or preserved ejection fraction, the immune system is activated and contributes to heart remodeling and impaired function. Recent Findings: Studies indicate that cells of the immune system not only play a role in the pathology but are also critical regulators of heart function. Knowledge about the role of the immune system driving heart failure will lead to the development of new targets to this system, particularly in those patients that, despite the apparent wellness, relapse and worsen. Summary: In this review, we will address the diverse mechanisms that trigger inflammation and their impact on heart failure progression.
KW - Acute inflammation
KW - Heart failure
KW - Inflammasome
KW - Reduced ejection fraction and preserved ejection fraction
KW - Systemic inflammation
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U2 - 10.1007/s11886-020-01382-2
DO - 10.1007/s11886-020-01382-2
M3 - Review article
C2 - 32910299
AN - SCOPUS:85090818249
VL - 22
JO - Current Cardiology Reports
JF - Current Cardiology Reports
SN - 1523-3782
IS - 11
M1 - 139
ER -