TY - JOUR
T1 - What does physics have to do with cancer?
AU - Michor, Franziska
AU - Liphardt, Jan
AU - Ferrari, Mauro
AU - Widom, Jonathan
N1 - Funding Information:
The authors would like to acknowledge support from the US National Cancer Institute Physical Sciences-Oncology Center (PSOC) initiative to fund the Dana-Farber Cancer Institute PSOC (F.M.), Bay Area PSOC (J.L.), The Methodist Hospital Research Institute PSOC (M.F.) and the Northwestern University PSOC (J.W.). M.F.’s research for this article was furthermore supported by grants from DoD/BCRP (W81XWH-09-1-0212), as well as by the Ernest Cockrell Jr. Distinguished Endowed Chair. The authors would like to thank A. Sebeson for her invaluable help. This work is dedicated to Professor Jonathan Widom. With his passing, we have lost both a major intellectual force and a valued member of our community, as well as a trusted friend and colleague.
PY - 2011/9
Y1 - 2011/9
N2 - Large-scale cancer genomics, proteomics and RNA-sequencing efforts are currently mapping in fine detail the genetic and biochemical alterations that occur in cancer. However, it is becoming clear that it is difficult to integrate and interpret these data and to translate them into treatments. This difficulty is compounded by the recognition that cancer cells evolve, and that initiation, progression and metastasis are influenced by a wide variety of factors. To help tackle this challenge, the US National Cancer Institute Physical Sciences-Oncology Centers initiative is bringing together physicists, cancer biologists, chemists, mathematicians and engineers. How are we beginning to address cancer from the perspective of the physical sciences?
AB - Large-scale cancer genomics, proteomics and RNA-sequencing efforts are currently mapping in fine detail the genetic and biochemical alterations that occur in cancer. However, it is becoming clear that it is difficult to integrate and interpret these data and to translate them into treatments. This difficulty is compounded by the recognition that cancer cells evolve, and that initiation, progression and metastasis are influenced by a wide variety of factors. To help tackle this challenge, the US National Cancer Institute Physical Sciences-Oncology Centers initiative is bringing together physicists, cancer biologists, chemists, mathematicians and engineers. How are we beginning to address cancer from the perspective of the physical sciences?
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U2 - 10.1038/nrc3092
DO - 10.1038/nrc3092
M3 - Review article
C2 - 21850037
AN - SCOPUS:80052038990
VL - 11
SP - 657
EP - 670
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 9
ER -