Weighty choices: Selecting optimal G-CSF doses for stem cell mobilization to optimize yield

Nosha Farhadfar, Jack W. Hsu, Brent R. Logan, Jennifer A. Sees, Pintip Chitphakdithai, Michele W. Sugrue, Hisham Abdel-Azim, Paolo N. Anderlini, Christopher Bredeson, Saurabh Chhabra, Miguel Angel Diaz, Siddhartha Ganguly, Peiman Hematti, Rammurti T. Kamble, Kimberly A. Kasow, Hillard M. Lazarus, Debra Kelly Lynch, Hemant S. Murthy, Richard F. Olsson, Mona PapariDonna Przepiorka, Bipin N. Savani, Raquel Schears, Sachiko Seo, Melhem M. Solh, Thomas Spitzer, Jean A. Yared, Michael A. Pulsipher, Nirali N. Shah, Galen E. Switzer, Dennis L. Confer, Bronwen E. Shaw, John R. Wingard

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

There are limited data on the effect of donor body mass index (BMI) on peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF), especially in unrelated donors. Obesity has been associated with persistent leukocytosis, elevated circulating progenitor cells, and enhanced stem cell mobilization. Therefore, we hypothesized that adequate collection of CD341 cells may be achieved with lower doses (per kilogram of body weight) of G-CSF in donors with higher BMI compared with donors with lower BMI. Using the Center for International Blood and Marrow Transplant Research database, we evaluated the impact of donor BMI on G-CSF-mobilized PBSC yield in healthy unrelated donors. We examined 20 884 PBSC donations collected at National Marrow Donor Program centers between 2006 and 2016. We found significantly higher collection yields in obese and severely obese donors compared with normal and overweight donors. An increase in average daily G-CSF dose was associated with an increase in stem cell yield in donors with normal or overweight BMI. In contrast, an increase in average daily G-CSF dose beyond 780 mg per day in obese and 900 mg per day in severely obese donors did not increase cell yield. Pain and toxicities were assessed at baseline, during G-CSF administration, and postcollection. Obesity was associated with higher levels of self-reported donation-related pain and toxicities in the pericollection and early postdonation recovery periods. This study suggests a maximum effective G-CSF dose for PBSC mobilization in obese and severely obese donors, beyond which higher doses of G-CSF add no increased yield.

Original languageEnglish (US)
Pages (from-to)706-716
Number of pages11
JournalBlood Advances
Volume4
Issue number4
DOIs
StatePublished - Feb 25 2020

ASJC Scopus subject areas

  • Hematology

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