TY - JOUR
T1 - Wastewater pandemic preparedness
T2 - Toward an end-to-end pathogen monitoring program
AU - TEPHI Wastewater Consortium
AU - Clark, Justin R.
AU - Terwilliger, Austen
AU - Avadhanula, Vasanthi
AU - Tisza, Michael
AU - Cormier, Juwan
AU - Javornik-Cregeen, Sara
AU - Ross, Matthew Clayton
AU - Hoffman, Kristi Louise
AU - Troisi, Catherine
AU - Hanson, Blake
AU - Petrosino, Joseph
AU - Balliew, John
AU - Piedra, Pedro A.
AU - Rios, Janelle
AU - Deegan, Jennifer
AU - Bauer, Cici
AU - Wu, Fuqing
AU - Mena, Kristina D.
AU - Boerwinkle, Eric
AU - Maresso, Anthony W.
N1 - Publisher Copyright:
Copyright © 2023 Clark, Terwilliger, Avadhanula, Tisza, Cormier, Javornik-Cregeen, Ross, Hoffman, Troisi, Hanson, Petrosino, Balliew, Piedra, Rios, Deegan, Bauer, Wu, Mena, Boerwinkle and Maresso.
PY - 2023
Y1 - 2023
N2 - Molecular analysis of public wastewater has great potential as a harbinger for community health and health threats. Long-used to monitor the presence of enteric viruses, in particular polio, recent successes of wastewater as a reliable lead indicator for trends in SARS-CoV-2 levels and hospital admissions has generated optimism and emerging evidence that similar science can be applied to other pathogens of pandemic potential (PPPs), especially respiratory viruses and their variants of concern (VOC). However, there are substantial challenges associated with implementation of this ideal, namely that multiple and distinct fields of inquiry must be bridged and coordinated. These include engineering, molecular sciences, temporal-geospatial analytics, epidemiology and medical, and governmental and public health messaging, all of which present their own caveats. Here, we outline a framework for an integrated, state-wide, end-to-end human pathogen monitoring program using wastewater to track viral PPPs.
AB - Molecular analysis of public wastewater has great potential as a harbinger for community health and health threats. Long-used to monitor the presence of enteric viruses, in particular polio, recent successes of wastewater as a reliable lead indicator for trends in SARS-CoV-2 levels and hospital admissions has generated optimism and emerging evidence that similar science can be applied to other pathogens of pandemic potential (PPPs), especially respiratory viruses and their variants of concern (VOC). However, there are substantial challenges associated with implementation of this ideal, namely that multiple and distinct fields of inquiry must be bridged and coordinated. These include engineering, molecular sciences, temporal-geospatial analytics, epidemiology and medical, and governmental and public health messaging, all of which present their own caveats. Here, we outline a framework for an integrated, state-wide, end-to-end human pathogen monitoring program using wastewater to track viral PPPs.
KW - detection
KW - early warning system
KW - epidemiologic
KW - pathogens
KW - public health
KW - virus
KW - wastewater
UR - http://www.scopus.com/inward/record.url?scp=85151910876&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85151910876&partnerID=8YFLogxK
U2 - 10.3389/fpubh.2023.1137881
DO - 10.3389/fpubh.2023.1137881
M3 - Article
C2 - 37026145
AN - SCOPUS:85151910876
SN - 2296-2565
VL - 11
JO - Frontiers in Public Health
JF - Frontiers in Public Health
M1 - 1137881
ER -