Von Willebrand factor contribution to pathophysiology outside of von Willebrand disease

Anahita Mojiri, Parnian Alavi, Nadia Jahroudi

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

VWF is a procoagulant protein that plays a central role in the initiation of platelets aggregate formation and thrombosis. While von Willebrand disease has long been known to result from qualitative and quantitative deficiencies of VWF, it is recently that contribution of elevated levels of VWF to various pathological conditions including thrombosis, inflammation, angiogenesis, and cancer metastasis has been appreciated. Here, we discuss contribution of elevated levels of VWF to various thrombotic and nonthrombotic pathological conditions.

Original languageEnglish (US)
Article numbere12510
JournalMicrocirculation
Volume26
Issue number4
DOIs
StatePublished - May 2019

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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