Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis

Ahmad M. Mansour, Edward Ferguson, Helen Lucia, Madhu Rajashekhar, Helen Li, Ted Margo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We investigated vitreous replacement by longlasting gas in the management of severe Staphylococcus aureus endophthalmitis in 19 rabbits randomized for vitrectomy (9 animals) and for vitrectomy followed by replacement of the vitreous by a 20% perfluoropropane-80% air mixture (10 animals). Both groups received systemic antibiotics and achieved comparable intraocular antibiotic levels. Clinically and histopathologically, gas-filled eyes demonstrated less inflammation than did eyes without gas (P < 0.01). Replacement of vitreous by gas offers an effective adjunct to vitrectomy by eliminating a culture medium, preventing vitreous abscess formation, enabling fundus visualization, and delaying the onset of retinal detachment.

Original languageEnglish (US)
Pages (from-to)468-472
Number of pages5
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number5
StatePublished - Sep 1991

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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