Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis

Ahmad M. Mansour; Edward Ferguson; Helen Lucia; Madhu Rajashekhar; Helen Li; Ted Margo

doi:10.1007/BF00166312

Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis

Ahmad M. Mansour, Edward Ferguson, Helen Lucia, Madhu Rajashekhar, Helen Li, Ted Margo

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We investigated vitreous replacement by longlasting gas in the management of severe Staphylococcus aureus endophthalmitis in 19 rabbits randomized for vitrectomy (9 animals) and for vitrectomy followed by replacement of the vitreous by a 20% perfluoropropane-80% air mixture (10 animals). Both groups received systemic antibiotics and achieved comparable intraocular antibiotic levels. Clinically and histopathologically, gas-filled eyes demonstrated less inflammation than did eyes without gas (P < 0.01). Replacement of vitreous by gas offers an effective adjunct to vitrectomy by eliminating a culture medium, preventing vitreous abscess formation, enabling fundus visualization, and delaying the onset of retinal detachment.

Original language	English (US)
Pages (from-to)	468-472
Number of pages	5
Journal	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume	229
Issue number	5
DOIs	https://doi.org/10.1007/BF00166312
State	Published - Sep 1991

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Access to Document

10.1007/BF00166312

Cite this

@article{0d923f8906f24520943c1ff38f0b7a4f,

title = "Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis",

abstract = "We investigated vitreous replacement by longlasting gas in the management of severe Staphylococcus aureus endophthalmitis in 19 rabbits randomized for vitrectomy (9 animals) and for vitrectomy followed by replacement of the vitreous by a 20% perfluoropropane-80% air mixture (10 animals). Both groups received systemic antibiotics and achieved comparable intraocular antibiotic levels. Clinically and histopathologically, gas-filled eyes demonstrated less inflammation than did eyes without gas (P < 0.01). Replacement of vitreous by gas offers an effective adjunct to vitrectomy by eliminating a culture medium, preventing vitreous abscess formation, enabling fundus visualization, and delaying the onset of retinal detachment.",

author = "Mansour, {Ahmad M.} and Edward Ferguson and Helen Lucia and Madhu Rajashekhar and Helen Li and Ted Margo",

year = "1991",

month = sep,

doi = "10.1007/BF00166312",

language = "English (US)",

volume = "229",

pages = "468--472",

journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",

issn = "0721-832X",

publisher = "Springer Verlag",

number = "5",

}

TY - JOUR

T1 - Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis

AU - Mansour, Ahmad M.

AU - Ferguson, Edward

AU - Lucia, Helen

AU - Rajashekhar, Madhu

AU - Li, Helen

AU - Margo, Ted

PY - 1991/9

Y1 - 1991/9

N2 - We investigated vitreous replacement by longlasting gas in the management of severe Staphylococcus aureus endophthalmitis in 19 rabbits randomized for vitrectomy (9 animals) and for vitrectomy followed by replacement of the vitreous by a 20% perfluoropropane-80% air mixture (10 animals). Both groups received systemic antibiotics and achieved comparable intraocular antibiotic levels. Clinically and histopathologically, gas-filled eyes demonstrated less inflammation than did eyes without gas (P < 0.01). Replacement of vitreous by gas offers an effective adjunct to vitrectomy by eliminating a culture medium, preventing vitreous abscess formation, enabling fundus visualization, and delaying the onset of retinal detachment.

AB - We investigated vitreous replacement by longlasting gas in the management of severe Staphylococcus aureus endophthalmitis in 19 rabbits randomized for vitrectomy (9 animals) and for vitrectomy followed by replacement of the vitreous by a 20% perfluoropropane-80% air mixture (10 animals). Both groups received systemic antibiotics and achieved comparable intraocular antibiotic levels. Clinically and histopathologically, gas-filled eyes demonstrated less inflammation than did eyes without gas (P < 0.01). Replacement of vitreous by gas offers an effective adjunct to vitrectomy by eliminating a culture medium, preventing vitreous abscess formation, enabling fundus visualization, and delaying the onset of retinal detachment.

UR - http://www.scopus.com/inward/record.url?scp=0025788514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025788514&partnerID=8YFLogxK

U2 - 10.1007/BF00166312

DO - 10.1007/BF00166312

M3 - Article

C2 - 1937081

AN - SCOPUS:0025788514

SN - 0721-832X

VL - 229

SP - 468

EP - 472

JO - Graefe's Archive for Clinical and Experimental Ophthalmology

JF - Graefe's Archive for Clinical and Experimental Ophthalmology

IS - 5

ER -

Vitreous replacement by gas as a therapeutic modality in bacterial endophthalmitis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this