TY - JOUR
T1 - Vitreomacular adhesion evolution with age in healthy human eyes
AU - Palacio, Agustina C.
AU - Gupta, Akash
AU - Nesmith, Brooke L.W.
AU - Jadav, Puja R.
AU - Schaal, Yam
AU - Schaal, Shlomit
N1 - Publisher Copyright:
Copyright © by Ophthalmic Communications Society, Inc.
PY - 2017
Y1 - 2017
N2 - Purpose: To quantify the changes in vitreomacular interactions that occur with normal aging in normal eyes. Methods: Spectral domain optical coherence tomography (SD-OCT, Spectralis; Heidelberg Engineering, Heidelberg, Germany) foveal scans of subjects with best corrected visual acuity better than 20/40 and no ocular pathology were included in the study. Each scan was analyzed to determine the status of vitreoretinal interface: complete vitreous adhesion, partial posterior vitreous detachment (PVD) with persistent vitreomacular adhesion (VMA), or complete PVD. Area of VMA was delineated using the Spectralis drawing tool and calculated in mm2 for each scan. Subjects, aged 10 years to 97 years, were divided into 9 age groups according to decade of life. Results: Five hundred and sixty-six SD-OCT scans were analyzed. Area of VMA (mm2) decreased sigmoidally (R2 = 0.99) with each decade of life. With aging, percentage of PVD increased while percentage of complete adhesion decreased. Males were found to have significantly larger area of VMA (mm2) compared with females in the fifth through eighth decades of life, P < 0.05. Conclusion: Vitreomacular interface interactions throughout life are age and gender dependent. This adds to our current understanding of the normal aging process undergone by the vitreous, thereby providing assistance in the clinical differentiation between normal and pathologic vitreomacular interactions.
AB - Purpose: To quantify the changes in vitreomacular interactions that occur with normal aging in normal eyes. Methods: Spectral domain optical coherence tomography (SD-OCT, Spectralis; Heidelberg Engineering, Heidelberg, Germany) foveal scans of subjects with best corrected visual acuity better than 20/40 and no ocular pathology were included in the study. Each scan was analyzed to determine the status of vitreoretinal interface: complete vitreous adhesion, partial posterior vitreous detachment (PVD) with persistent vitreomacular adhesion (VMA), or complete PVD. Area of VMA was delineated using the Spectralis drawing tool and calculated in mm2 for each scan. Subjects, aged 10 years to 97 years, were divided into 9 age groups according to decade of life. Results: Five hundred and sixty-six SD-OCT scans were analyzed. Area of VMA (mm2) decreased sigmoidally (R2 = 0.99) with each decade of life. With aging, percentage of PVD increased while percentage of complete adhesion decreased. Males were found to have significantly larger area of VMA (mm2) compared with females in the fifth through eighth decades of life, P < 0.05. Conclusion: Vitreomacular interface interactions throughout life are age and gender dependent. This adds to our current understanding of the normal aging process undergone by the vitreous, thereby providing assistance in the clinical differentiation between normal and pathologic vitreomacular interactions.
KW - Normal aging
KW - Optical coherence tomography
KW - Posterior vitreous detachment
KW - Vitreomacular adhesion
KW - Vitreomacular interaction
KW - Vitreoretinal interface
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U2 - 10.1097/IAE.0000000000001115
DO - 10.1097/IAE.0000000000001115
M3 - Article
C2 - 27306115
AN - SCOPUS:84974851939
VL - 37
SP - 118
EP - 123
JO - Retina
JF - Retina
SN - 0275-004X
IS - 1
ER -