Vitreomacular adhesion evolution with age in healthy human eyes

Agustina C. Palacio, Akash Gupta, Brooke L.W. Nesmith, Puja R. Jadav, Yam Schaal, Shlomit Schaal

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Purpose: To quantify the changes in vitreomacular interactions that occur with normal aging in normal eyes. Methods: Spectral domain optical coherence tomography (SD-OCT, Spectralis; Heidelberg Engineering, Heidelberg, Germany) foveal scans of subjects with best corrected visual acuity better than 20/40 and no ocular pathology were included in the study. Each scan was analyzed to determine the status of vitreoretinal interface: complete vitreous adhesion, partial posterior vitreous detachment (PVD) with persistent vitreomacular adhesion (VMA), or complete PVD. Area of VMA was delineated using the Spectralis drawing tool and calculated in mm2 for each scan. Subjects, aged 10 years to 97 years, were divided into 9 age groups according to decade of life. Results: Five hundred and sixty-six SD-OCT scans were analyzed. Area of VMA (mm2) decreased sigmoidally (R2 = 0.99) with each decade of life. With aging, percentage of PVD increased while percentage of complete adhesion decreased. Males were found to have significantly larger area of VMA (mm2) compared with females in the fifth through eighth decades of life, P < 0.05. Conclusion: Vitreomacular interface interactions throughout life are age and gender dependent. This adds to our current understanding of the normal aging process undergone by the vitreous, thereby providing assistance in the clinical differentiation between normal and pathologic vitreomacular interactions.

Original languageEnglish (US)
Pages (from-to)118-123
Number of pages6
Issue number1
StatePublished - 2017


  • Normal aging
  • Optical coherence tomography
  • Posterior vitreous detachment
  • Vitreomacular adhesion
  • Vitreomacular interaction
  • Vitreoretinal interface

ASJC Scopus subject areas

  • Ophthalmology


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