Vitamin D and multiple sclerosis: A critical review and recommendations on treatment

Alireza Faridar, Ghazaleh Eskandari, Mohammad Ali Sahraian, Alireza Minagar, Amirreza Azimi

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients.

Original languageEnglish (US)
Pages (from-to)327-333
Number of pages7
JournalActa Neurologica Belgica
Issue number4
StatePublished - Dec 2012


  • Demyelinating
  • Multiple sclerosis
  • Prevention
  • Vitamin D

ASJC Scopus subject areas

  • Clinical Neurology


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