Vitamin A: adjuvant and steroid antagonist in the immune response

B. E. Cohen, I. K. Cohen

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

The effects of vitamin A and hydrocortisone on the immune response were studied in the mouse. Vitamin A treatment alone markedly increased the normal number of antibody forming cells generated in the spleen in response to immunization with sheep red blood cells. The antibody response to immunization with dinitrophenylated ovalbumin (DNP OVA), a hapten protein conjugate, was also enhanced by vitamin A pretreatment. Furthermore, the immunosuppressive effect of hydrocortisone on the response to sheep red blood cells could be prevented by simultaneous administration of vitamin A.

Original languageEnglish (US)
Pages (from-to)1376-1380
Number of pages5
JournalJournal of Immunology
Volume111
Issue number5
StatePublished - 1973

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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