Virus interactions with the actin cytoskeleton—what we know and do not know about SARS-CoV-2

Malgorzata Kloc, Ahmed Uosef, Jarek Wosik, Jacek Z. Kubiak, Rafik M. Ghobrial

Research output: Contribution to journalReview articlepeer-review

Abstract

The actin cytoskeleton and actin-dependent molecular and cellular events are responsible for the organization of eukaryotic cells and their functions. Viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), depend on host cell organelles and molecular components for cell entry and propagation. Thus, it is not surprising that they also interact at many levels with the actin cytoskeleton of the host. There have been many studies on how different viruses reconfigure and manipulate the actin cytoskeleton of the host during successive steps of their life cycle. However, we know relatively little about the interactions of SARS-CoV-2 with the actin cytoskeleton. Here, we describe how the actin cytoskeleton is involved in the strategies used by different viruses for entry, assembly, and egress from the host cell. We emphasize what is known and unknown about SARS-CoV-2 in this regard. This review should encourage further investigation of the interactions of SARS-CoV-2 with cellular components, which will eventually be helpful for developing novel antiviral therapies for mitigating the severity of COVID-19.

Original languageEnglish (US)
Pages (from-to)737-749
Number of pages13
JournalArchives of Virology
Volume167
Issue number3
DOIs
StatePublished - Mar 2022

ASJC Scopus subject areas

  • Virology

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