The binding events of the baculovirus was measured using arrays of chemically functionalized, surface micromachined polycrystalline silicon cantilevers. The 0.5 μm×6 μm cantilevers have mass sensitivities on the order of 10 -19 g/Hz, that enables to detect an immobilized AcV1 antibody monolayer corresponsing to mass of about 3×10 -15 g. The resonant frequency shift was observed from the adsorbed mass of the virus particles distinguished solutions of virus concentrations and varies between 10 5 and 10 7 pfu/ml. The mass of single-virus particles bound to the cantilever can also be detected using cantilevers.
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)