TY - JOUR
T1 - Virtual hepatic venous pressure gradient with CT angiography (Chess 1601)
T2 - A prospective multicenter study for the noninvasive diagnosis of portal hypertension
AU - Qi, Xiaolong
AU - An, Weimin
AU - Liu, Fuquan
AU - Qi, Ruizhao
AU - Wang, Lei
AU - Liu, Yanna
AU - Liu, Chuan
AU - Xiang, Yi
AU - Hui, Jialiang
AU - Liu, Zhao
AU - Qi, Xingshun
AU - Liu, Changchun
AU - Peng, Baogang
AU - Ding, Huiguo
AU - Yang, Yongping
AU - He, Xiaoshun
AU - Hou, Jinlin
AU - Tian, Jie
AU - Li, Zhiwei
N1 - Publisher Copyright:
© RSNA, 2018
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Purpose: To develop and validate a computational model for estimating hepatic venous pressure gradient (HVPG) based on CT angiographic images, termed virtual HVPG, to enable the noninvasive diagnosis of portal hypertension in patients with cirrhosis. Materials and Methods: In this prospective multicenter diagnostic trial (ClinicalTrials.gov identifier: NCT02842697), 102 consecutive eligible participants (mean age, 47 years [range, 21–75 years]; 68 men with a mean age of 44 years [range, 21–73 years] and 34 women with a mean age of 52 years [range, 24–75 years]) were recruited from three high-volume liver centers between August 2016 and April 2017. All participants with cirrhosis of various causes underwent transjugular HVPG measurement, Doppler US, and CT angiography. Virtual HVPG was developed with a three-dimensional reconstructed model and computational fluid dynamics. Results: In the training cohort (n = 29), the area under the receiver operating characteristic curve (AUC) of virtual HVPG in the prediction of clinically significant portal hypertension (CSPH) was 0.83 (95% confidence interval [CI]: 0.58, 1.00). The diagnostic performance was prospectively confirmed in the validation cohort (n = 73), with an AUC of 0.89 (95% CI: 0.81, 0.96). Inter- and intraobserver agreement was 0.88 and 0.96, respectively, suggesting the good reproducibility of virtual HVPG measurements. There was good correlation between virtual HVPG and invasive HVPG (R = 0.61, P , .001), with a satisfactory performance to rule out (7.3 mm Hg) and rule in (13.0 mm Hg) CSPH. Conclusion: The accuracy of a computational model of virtual hepatic venous pressure gradient (HVPG) shows significant correlation with invasive HVPG. The virtual HVPG also showed a good performance in the noninvasive diagnosis of clinically significant portal hypertension in cirrhosis.
AB - Purpose: To develop and validate a computational model for estimating hepatic venous pressure gradient (HVPG) based on CT angiographic images, termed virtual HVPG, to enable the noninvasive diagnosis of portal hypertension in patients with cirrhosis. Materials and Methods: In this prospective multicenter diagnostic trial (ClinicalTrials.gov identifier: NCT02842697), 102 consecutive eligible participants (mean age, 47 years [range, 21–75 years]; 68 men with a mean age of 44 years [range, 21–73 years] and 34 women with a mean age of 52 years [range, 24–75 years]) were recruited from three high-volume liver centers between August 2016 and April 2017. All participants with cirrhosis of various causes underwent transjugular HVPG measurement, Doppler US, and CT angiography. Virtual HVPG was developed with a three-dimensional reconstructed model and computational fluid dynamics. Results: In the training cohort (n = 29), the area under the receiver operating characteristic curve (AUC) of virtual HVPG in the prediction of clinically significant portal hypertension (CSPH) was 0.83 (95% confidence interval [CI]: 0.58, 1.00). The diagnostic performance was prospectively confirmed in the validation cohort (n = 73), with an AUC of 0.89 (95% CI: 0.81, 0.96). Inter- and intraobserver agreement was 0.88 and 0.96, respectively, suggesting the good reproducibility of virtual HVPG measurements. There was good correlation between virtual HVPG and invasive HVPG (R = 0.61, P , .001), with a satisfactory performance to rule out (7.3 mm Hg) and rule in (13.0 mm Hg) CSPH. Conclusion: The accuracy of a computational model of virtual hepatic venous pressure gradient (HVPG) shows significant correlation with invasive HVPG. The virtual HVPG also showed a good performance in the noninvasive diagnosis of clinically significant portal hypertension in cirrhosis.
UR - http://www.scopus.com/inward/record.url?scp=85060371953&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060371953&partnerID=8YFLogxK
U2 - 10.1148/radiol.2018180425
DO - 10.1148/radiol.2018180425
M3 - Article
C2 - 30457484
AN - SCOPUS:85060371953
SN - 0033-8419
VL - 290
SP - 370
EP - 377
JO - Radiology
JF - Radiology
IS - 3
ER -