Verrucous carcinoma of the esophagus: A potential diagnostic dilemma

Kabir Ahmed, Gary Timmerman, Robert Meyer, Tara Miller, Miroslaw Mazurczak, Kimberlee Tams, Muslim Atiq

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Verrucous carcinoma of the esophagus is a rare variant of squamous cell carcinoma associated with human papillomavirus. We report the case of a 58-year-old female who presented with ongoing symptoms of dysphagia. On previous endoscopies she had been noted to have a large polyp-like mass involving the esophagus, with negative biopsies for malignancy. Repeat endoscopy with concurrent endoscopic ultrasound showed a large semi-pedunculated polyp in the distal esophagus and a hypoechoic, irregular mass involving the gastroesophageal junction with esophageal thickening. Deep layer biopsies showed pseudoepitheliomatous hyperplasia with immunohistochemical staining positive for human papillomavirus. The patient was subsequently treated with chemo-radiation followed by esophagectomy.

Original languageEnglish (US)
Pages (from-to)498-502
Number of pages5
JournalCase Reports in Gastroenterology
Issue number3
StatePublished - 2013


  • Esophagus
  • Human papillomavirus
  • Verrucous carcinoma

ASJC Scopus subject areas

  • Gastroenterology


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