Verrucous carcinoma of the esophagus: A potential diagnostic dilemma

Kabir Ahmed; Gary Timmerman; Robert Meyer; Tara Miller; Miroslaw Mazurczak; Kimberlee Tams; Muslim Atiq

doi:10.1159/000357303

Verrucous carcinoma of the esophagus: A potential diagnostic dilemma

Kabir Ahmed, Gary Timmerman, Robert Meyer, Tara Miller, Miroslaw Mazurczak, Kimberlee Tams, Muslim Atiq

Research output: Contribution to journal › Article

8 Scopus citations

Abstract

Verrucous carcinoma of the esophagus is a rare variant of squamous cell carcinoma associated with human papillomavirus. We report the case of a 58-year-old female who presented with ongoing symptoms of dysphagia. On previous endoscopies she had been noted to have a large polyp-like mass involving the esophagus, with negative biopsies for malignancy. Repeat endoscopy with concurrent endoscopic ultrasound showed a large semi-pedunculated polyp in the distal esophagus and a hypoechoic, irregular mass involving the gastroesophageal junction with esophageal thickening. Deep layer biopsies showed pseudoepitheliomatous hyperplasia with immunohistochemical staining positive for human papillomavirus. The patient was subsequently treated with chemo-radiation followed by esophagectomy.

Original language	English (US)
Pages (from-to)	498-502
Number of pages	5
Journal	Case Reports in Gastroenterology
Volume	7
Issue number	3
DOIs	https://doi.org/10.1159/000357303
State	Published - 2013

Keywords

Esophagus
Human papillomavirus
Verrucous carcinoma

ASJC Scopus subject areas

Gastroenterology

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10.1159/000357303

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abstract = "Verrucous carcinoma of the esophagus is a rare variant of squamous cell carcinoma associated with human papillomavirus. We report the case of a 58-year-old female who presented with ongoing symptoms of dysphagia. On previous endoscopies she had been noted to have a large polyp-like mass involving the esophagus, with negative biopsies for malignancy. Repeat endoscopy with concurrent endoscopic ultrasound showed a large semi-pedunculated polyp in the distal esophagus and a hypoechoic, irregular mass involving the gastroesophageal junction with esophageal thickening. Deep layer biopsies showed pseudoepitheliomatous hyperplasia with immunohistochemical staining positive for human papillomavirus. The patient was subsequently treated with chemo-radiation followed by esophagectomy.",

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AU - Ahmed, Kabir

AU - Timmerman, Gary

AU - Meyer, Robert

AU - Miller, Tara

AU - Mazurczak, Miroslaw

AU - Tams, Kimberlee

AU - Atiq, Muslim

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AB - Verrucous carcinoma of the esophagus is a rare variant of squamous cell carcinoma associated with human papillomavirus. We report the case of a 58-year-old female who presented with ongoing symptoms of dysphagia. On previous endoscopies she had been noted to have a large polyp-like mass involving the esophagus, with negative biopsies for malignancy. Repeat endoscopy with concurrent endoscopic ultrasound showed a large semi-pedunculated polyp in the distal esophagus and a hypoechoic, irregular mass involving the gastroesophageal junction with esophageal thickening. Deep layer biopsies showed pseudoepitheliomatous hyperplasia with immunohistochemical staining positive for human papillomavirus. The patient was subsequently treated with chemo-radiation followed by esophagectomy.

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