Vasculature organotropism in drug delivery

A. Amruta, Dalila Iannotta, Seth W. Cheetham, Twan Lammers, Joy Wolfram

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Over the past decades, there has been an exponential increase in the development of preclinical and clinical nanodelivery systems, and recently, an accelerating demand to deliver RNA and protein-based therapeutics. Organ-specific vasculature provides a promising intermediary for site-specific delivery of nanoparticles and extracellular vesicles to interstitial cells. Endothelial cells express organ-specific surface marker repertoires that can be used for targeted delivery. This article highlights organ-specific vasculature properties, nanodelivery strategies that exploit vasculature organotropism, and overlooked challenges and opportunities in targeting and simultaneously overcoming the endothelial barrier. Impediments in the clinical translation of vasculature organotropism in drug delivery are also discussed.

Original languageEnglish (US)
Article number115054
Pages (from-to)115054
JournalAdvanced Drug Delivery Reviews
StatePublished - Oct 2023


  • Drug delivery
  • Endothelial barrier
  • Extracellular vesicles
  • Nanodelivery
  • Organ-specific

ASJC Scopus subject areas

  • Pharmaceutical Science


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