Vascular Inflammation: A Novel Access Route for Nanomedicine

Roberto Molinaro, Christian Boada, Guillermo Medrano Del Rosal, Kelly A. Hartman, Claudia Corbo, Elizabeth D. Andrews, Naama E. Toledano-Furman, John P. Cooke, Ennio Tasciotti

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Despite an improved understanding of its pathophysiology and a wide range of new treatments, cardiovascular disease (CVD) remains a serious public health issue and the number one cause of mortality in the United States. Conditions that promote chronic systemic inflammation, such as obesity, cancer, and autoimmune and infectious diseases, are now known to play an important role in promoting CVD by inducing the expression of endothelial adhesion molecules and chemokines; these in turn promote leukocyte adherence and infiltration, which initiates and spurs the progression of CVD. In response to this new understanding, researchers are evaluating the potential cardiovascular benefits of new-generation therapies based on endogenous molecules with anti-inflammatory properties. Similarly, targeted approaches that leverage the phenotypic differences between non-inflamed and inflamed endothelia have the potential to selectively deliver therapeutics and decrease the morbidity and mortality of CVD patients. In this review, we discuss the role of inflammation in CVD and explore the therapeutic potential of targeting inflamed vasculature through conventional and biomimetic approaches.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalMethodist DeBakey cardiovascular journal
Volume12
Issue number3
DOIs
StatePublished - Sep 2016

Keywords

  • C-reactive protein
  • cardiovascular diseases
  • drug delivery platform
  • endotheliopathies
  • endothelium
  • NF-kB
  • statins
  • theranostic
  • vascular inflammation

ASJC Scopus subject areas

  • Medicine(all)

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