Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world: The I-DARE study

Research output: Contribution to journalArticle

CRIC Study Investigators, Paul E. Drawz, Roland Brown, Luca De Nicola, Naohiko Fujii, Francis B. Gabbai, Jennifer Gassman, Jiang He, Satoshi Iimuro, James Lash, Roberto Minutolo, Robert A. Phillips, Kyle Rudser, Luis Ruilope, Susan Steigerwalt, Raymond R. Townsend, Dawei Xie, Mahboob Rahman

Background and objectives Ambulatory BP is increasingly recognized as a better measure of the risk for adverse outcomes related to hypertension, an important comorbidity in patients with CKD. Varying definitions of white-coat and masked hypertension have made it difficult to evaluate differences in prevalence of these BP patterns across CKD cohorts. Design, setting, participants, & measurements The International Database of Ambulatory BP in Renal Patients collaborative group established a large database of demographic, clinical, and ambulatory BP data from patients with CKD from cohorts in Italy, Spain, the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study of Kidney Disease and Hypertension Cohort Study (AASK) in the United States, and the CKD Japan Cohort (CKD-JAC). Participants (n=7518) with CKD were included in the present analyses. Cutoffs for defining controlled BP were 140/90 mm Hg for clinic and 130/80 mm Hg for 24-hour ambulatory BP. Results Among those with controlled clinic BP, compared with CKD-JAC, AASK participants were more likely to have masked hypertension (prevalence ratio [PR], 1.21; 95% confidence interval [95% CI], 1.04 to 1.41) whereas CRIC (PR, 0.82; 0.72 to 0.94), Italian (PR, 0.73; 0.56 to 0.95), and Spanish participants (PR, 0.75; 0.64 to 0.88) were less likely. Among those with elevated clinic BP, AASK participants were more likely to have sustained hypertension (PR, 1.22; 95% CI, 1.13 to 1.32) whereas Italian (PR, 0.78; 0.70 to 0.87) and Spanish participants (PR, 0.89; 0.82 to 0.96) were less likely, although CRIC participants had similar prevalence as CKD-JAC. Prevalence of masked and sustained hypertension was elevated in males, patients with diabetes, participants on four or more antihyper-tensives, and those with moderate-to-severe proteinuria. Conclusions In a large, multinational database, the prevalence of masked and sustained hypertension varied across cohorts independent of important comorbidities.

Original languageEnglish (US)
Pages (from-to)1348-1357
Number of pages10
JournalClinical Journal of the American Society of Nephrology
Volume13
Issue number9
DOIs
StatePublished - Sep 7 2018

PMID: 29976600

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Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world : The I-DARE study. / CRIC Study Investigators.

In: Clinical Journal of the American Society of Nephrology, Vol. 13, No. 9, 07.09.2018, p. 1348-1357.

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Harvard

CRIC Study Investigators 2018, 'Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world: The I-DARE study' Clinical Journal of the American Society of Nephrology, vol. 13, no. 9, pp. 1348-1357. https://doi.org/10.2215/CJN.13181117

APA

CRIC Study Investigators (2018). Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world: The I-DARE study. Clinical Journal of the American Society of Nephrology, 13(9), 1348-1357. https://doi.org/10.2215/CJN.13181117

Vancouver

CRIC Study Investigators. Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world: The I-DARE study. Clinical Journal of the American Society of Nephrology. 2018 Sep 7;13(9):1348-1357. https://doi.org/10.2215/CJN.13181117

Author

CRIC Study Investigators. / Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world : The I-DARE study. In: Clinical Journal of the American Society of Nephrology. 2018 ; Vol. 13, No. 9. pp. 1348-1357.

BibTeX

@article{34e91a410ef44f8bb702c281a46e72dc,
title = "Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world: The I-DARE study",
abstract = "Background and objectives Ambulatory BP is increasingly recognized as a better measure of the risk for adverse outcomes related to hypertension, an important comorbidity in patients with CKD. Varying definitions of white-coat and masked hypertension have made it difficult to evaluate differences in prevalence of these BP patterns across CKD cohorts. Design, setting, participants, & measurements The International Database of Ambulatory BP in Renal Patients collaborative group established a large database of demographic, clinical, and ambulatory BP data from patients with CKD from cohorts in Italy, Spain, the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study of Kidney Disease and Hypertension Cohort Study (AASK) in the United States, and the CKD Japan Cohort (CKD-JAC). Participants (n=7518) with CKD were included in the present analyses. Cutoffs for defining controlled BP were 140/90 mm Hg for clinic and 130/80 mm Hg for 24-hour ambulatory BP. Results Among those with controlled clinic BP, compared with CKD-JAC, AASK participants were more likely to have masked hypertension (prevalence ratio [PR], 1.21; 95{\%} confidence interval [95{\%} CI], 1.04 to 1.41) whereas CRIC (PR, 0.82; 0.72 to 0.94), Italian (PR, 0.73; 0.56 to 0.95), and Spanish participants (PR, 0.75; 0.64 to 0.88) were less likely. Among those with elevated clinic BP, AASK participants were more likely to have sustained hypertension (PR, 1.22; 95{\%} CI, 1.13 to 1.32) whereas Italian (PR, 0.78; 0.70 to 0.87) and Spanish participants (PR, 0.89; 0.82 to 0.96) were less likely, although CRIC participants had similar prevalence as CKD-JAC. Prevalence of masked and sustained hypertension was elevated in males, patients with diabetes, participants on four or more antihyper-tensives, and those with moderate-to-severe proteinuria. Conclusions In a large, multinational database, the prevalence of masked and sustained hypertension varied across cohorts independent of important comorbidities.",
author = "{CRIC Study Investigators} and Drawz, {Paul E.} and Roland Brown and {De Nicola}, Luca and Naohiko Fujii and Gabbai, {Francis B.} and Jennifer Gassman and Jiang He and Satoshi Iimuro and James Lash and Roberto Minutolo and Phillips, {Robert A.} and Kyle Rudser and Luis Ruilope and Susan Steigerwalt and Townsend, {Raymond R.} and Dawei Xie and Mahboob Rahman",
year = "2018",
month = "9",
day = "7",
doi = "10.2215/CJN.13181117",
language = "English (US)",
volume = "13",
pages = "1348--1357",
journal = "Clinical Journal of the American Society of Nephrology",
issn = "1555-9041",
publisher = "American Society of Nephrology",
number = "9",

}

RIS

TY - JOUR

T1 - Variations in 24-hour BP profiles in cohorts of patients with kidney disease around the world

T2 - Clinical Journal of the American Society of Nephrology

AU - CRIC Study Investigators

AU - Drawz, Paul E.

AU - Brown, Roland

AU - De Nicola, Luca

AU - Fujii, Naohiko

AU - Gabbai, Francis B.

AU - Gassman, Jennifer

AU - He, Jiang

AU - Iimuro, Satoshi

AU - Lash, James

AU - Minutolo, Roberto

AU - Phillips, Robert A.

AU - Rudser, Kyle

AU - Ruilope, Luis

AU - Steigerwalt, Susan

AU - Townsend, Raymond R.

AU - Xie, Dawei

AU - Rahman, Mahboob

PY - 2018/9/7

Y1 - 2018/9/7

N2 - Background and objectives Ambulatory BP is increasingly recognized as a better measure of the risk for adverse outcomes related to hypertension, an important comorbidity in patients with CKD. Varying definitions of white-coat and masked hypertension have made it difficult to evaluate differences in prevalence of these BP patterns across CKD cohorts. Design, setting, participants, & measurements The International Database of Ambulatory BP in Renal Patients collaborative group established a large database of demographic, clinical, and ambulatory BP data from patients with CKD from cohorts in Italy, Spain, the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study of Kidney Disease and Hypertension Cohort Study (AASK) in the United States, and the CKD Japan Cohort (CKD-JAC). Participants (n=7518) with CKD were included in the present analyses. Cutoffs for defining controlled BP were 140/90 mm Hg for clinic and 130/80 mm Hg for 24-hour ambulatory BP. Results Among those with controlled clinic BP, compared with CKD-JAC, AASK participants were more likely to have masked hypertension (prevalence ratio [PR], 1.21; 95% confidence interval [95% CI], 1.04 to 1.41) whereas CRIC (PR, 0.82; 0.72 to 0.94), Italian (PR, 0.73; 0.56 to 0.95), and Spanish participants (PR, 0.75; 0.64 to 0.88) were less likely. Among those with elevated clinic BP, AASK participants were more likely to have sustained hypertension (PR, 1.22; 95% CI, 1.13 to 1.32) whereas Italian (PR, 0.78; 0.70 to 0.87) and Spanish participants (PR, 0.89; 0.82 to 0.96) were less likely, although CRIC participants had similar prevalence as CKD-JAC. Prevalence of masked and sustained hypertension was elevated in males, patients with diabetes, participants on four or more antihyper-tensives, and those with moderate-to-severe proteinuria. Conclusions In a large, multinational database, the prevalence of masked and sustained hypertension varied across cohorts independent of important comorbidities.

AB - Background and objectives Ambulatory BP is increasingly recognized as a better measure of the risk for adverse outcomes related to hypertension, an important comorbidity in patients with CKD. Varying definitions of white-coat and masked hypertension have made it difficult to evaluate differences in prevalence of these BP patterns across CKD cohorts. Design, setting, participants, & measurements The International Database of Ambulatory BP in Renal Patients collaborative group established a large database of demographic, clinical, and ambulatory BP data from patients with CKD from cohorts in Italy, Spain, the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study of Kidney Disease and Hypertension Cohort Study (AASK) in the United States, and the CKD Japan Cohort (CKD-JAC). Participants (n=7518) with CKD were included in the present analyses. Cutoffs for defining controlled BP were 140/90 mm Hg for clinic and 130/80 mm Hg for 24-hour ambulatory BP. Results Among those with controlled clinic BP, compared with CKD-JAC, AASK participants were more likely to have masked hypertension (prevalence ratio [PR], 1.21; 95% confidence interval [95% CI], 1.04 to 1.41) whereas CRIC (PR, 0.82; 0.72 to 0.94), Italian (PR, 0.73; 0.56 to 0.95), and Spanish participants (PR, 0.75; 0.64 to 0.88) were less likely. Among those with elevated clinic BP, AASK participants were more likely to have sustained hypertension (PR, 1.22; 95% CI, 1.13 to 1.32) whereas Italian (PR, 0.78; 0.70 to 0.87) and Spanish participants (PR, 0.89; 0.82 to 0.96) were less likely, although CRIC participants had similar prevalence as CKD-JAC. Prevalence of masked and sustained hypertension was elevated in males, patients with diabetes, participants on four or more antihyper-tensives, and those with moderate-to-severe proteinuria. Conclusions In a large, multinational database, the prevalence of masked and sustained hypertension varied across cohorts independent of important comorbidities.

UR - http://www.scopus.com/inward/record.url?scp=85053306889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053306889&partnerID=8YFLogxK

U2 - 10.2215/CJN.13181117

DO - 10.2215/CJN.13181117

M3 - Article

VL - 13

SP - 1348

EP - 1357

JO - Clinical Journal of the American Society of Nephrology

JF - Clinical Journal of the American Society of Nephrology

SN - 1555-9041

IS - 9

ER -

ID: 40954959