TY - JOUR
T1 - Variably protease-sensitive prionopathy
T2 - A differential diagnostic consideration for dementia
AU - Kim, Stella H.
AU - Yu, Melissa M.
AU - Strutt, Adriana M.
N1 - Publisher Copyright:
© American Academy of Neurology.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Purpose of reviewPrion diseases are rare neurodegenerative diseases that are caused by abnormal pathogenic agents and can affect both humans and animals. These diseases are categorized as sporadic, inherited, or acquired by infection. Clinical manifestations include psychiatric symptoms, cognitive impairment, and parkinsonism, which are similar to those of other prion diseases and frontotemporal dementia variants.Recent findingsMore recently, scientists discovered a new sporadic prion disease called variably protease-sensitive prionopathy.SummaryThe following case discusses a patient presenting with sudden onset and rapid decline in cognitive, neurobehavioral, and motor functioning and his clinical journey including treatment interventions and diagnostic confirmation.
AB - Purpose of reviewPrion diseases are rare neurodegenerative diseases that are caused by abnormal pathogenic agents and can affect both humans and animals. These diseases are categorized as sporadic, inherited, or acquired by infection. Clinical manifestations include psychiatric symptoms, cognitive impairment, and parkinsonism, which are similar to those of other prion diseases and frontotemporal dementia variants.Recent findingsMore recently, scientists discovered a new sporadic prion disease called variably protease-sensitive prionopathy.SummaryThe following case discusses a patient presenting with sudden onset and rapid decline in cognitive, neurobehavioral, and motor functioning and his clinical journey including treatment interventions and diagnostic confirmation.
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U2 - 10.1212/CPJ.0000000000000612
DO - 10.1212/CPJ.0000000000000612
M3 - Review article
AN - SCOPUS:85073635981
SN - 2163-0402
VL - 9
SP - 145
EP - 151
JO - Neurology: Clinical Practice
JF - Neurology: Clinical Practice
IS - 2
ER -