Variably protease-sensitive prionopathy: A differential diagnostic consideration for dementia

Stella H. Kim, Melissa M. Yu, Adriana M. Strutt

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Purpose of reviewPrion diseases are rare neurodegenerative diseases that are caused by abnormal pathogenic agents and can affect both humans and animals. These diseases are categorized as sporadic, inherited, or acquired by infection. Clinical manifestations include psychiatric symptoms, cognitive impairment, and parkinsonism, which are similar to those of other prion diseases and frontotemporal dementia variants.Recent findingsMore recently, scientists discovered a new sporadic prion disease called variably protease-sensitive prionopathy.SummaryThe following case discusses a patient presenting with sudden onset and rapid decline in cognitive, neurobehavioral, and motor functioning and his clinical journey including treatment interventions and diagnostic confirmation.

Original languageEnglish (US)
Pages (from-to)145-151
Number of pages7
JournalNeurology: Clinical Practice
Volume9
Issue number2
DOIs
StatePublished - Apr 1 2019

ASJC Scopus subject areas

  • Clinical Neurology

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