Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells

Tianhong Pan; Xinqun Li; Wenjie Xie; Joseph Jankovic; Weidong Le

doi:10.1016/j.febslet.2005.10.067

Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells

Tianhong Pan, Xinqun Li, Wenjie Xie, Joseph Jankovic, Weidong Le

Houston Methodist

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection.

Original language	English (US)
Pages (from-to)	6716-6720
Number of pages	5
Journal	FEBS Letters
Volume	579
Issue number	30
DOIs	https://doi.org/10.1016/j.febslet.2005.10.067
State	Published - Dec 19 2005

Keywords

Heat shock protein
Hsp70
Neuroprotection
p-Akt
p-B cell lymphoma protein-2
Phospho-p44/42 mitogen-activated protein kinase
Valproic acid

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/j.febslet.2005.10.067

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title = "Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells",

abstract = "Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection.",

keywords = "Heat shock protein, Hsp70, Neuroprotection, p-Akt, p-B cell lymphoma protein-2, Phospho-p44/42 mitogen-activated protein kinase, Valproic acid",

author = "Tianhong Pan and Xinqun Li and Wenjie Xie and Joseph Jankovic and Weidong Le",

note = "Funding Information: This study was supported by grant for NINDS (40370 and 043567).",

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TY - JOUR

T1 - Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells

AU - Pan, Tianhong

AU - Li, Xinqun

AU - Xie, Wenjie

AU - Jankovic, Joseph

AU - Le, Weidong

N1 - Funding Information: This study was supported by grant for NINDS (40370 and 043567).

PY - 2005/12/19

Y1 - 2005/12/19

N2 - Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection.

AB - Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection.

KW - Heat shock protein

KW - Hsp70

KW - Neuroprotection

KW - p-Akt

KW - p-B cell lymphoma protein-2

KW - Phospho-p44/42 mitogen-activated protein kinase

KW - Valproic acid

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DO - 10.1016/j.febslet.2005.10.067

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AN - SCOPUS:28844480953

SN - 0014-5793

VL - 579

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JO - FEBS Letters

JF - FEBS Letters

IS - 30

ER -

Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells

Abstract

Keywords

ASJC Scopus subject areas

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