Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells

Tianhong Pan, Xinqun Li, Wenjie Xie, Joseph Jankovic, Weidong Le

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug, has been reported to exert neuroprotection against a variety of insults. We now show that VPA attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. Activation of p-Akt, p-Bcl-2, as well as p-Erk1/2 by VPA may be co-contributors to the protection.

Original languageEnglish (US)
Pages (from-to)6716-6720
Number of pages5
JournalFEBS Letters
Volume579
Issue number30
DOIs
StatePublished - Dec 19 2005

Keywords

  • Heat shock protein
  • Hsp70
  • Neuroprotection
  • p-Akt
  • p-B cell lymphoma protein-2
  • Phospho-p44/42 mitogen-activated protein kinase
  • Valproic acid

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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