Vaccine therapies for pediatric malignancies

Raphaël F. Rousseau, Malcolm Brenner

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Cancer vaccines are examples of active immunotherapy. In pediatric malignancy such active strategies may be particularly problematic because of immune suppression produced by the tumor or its intensive treatment with combined chemotherapy. Nonetheless, the expression of tumor-specific and tumor-associated antigens on a range of pediatric tumors has encouraged investigation of the approach in patients with either bulky or minimal residual disease. Here we describe promising results in neuroblastoma and acute leukemia, suing genetically modified whole cell vaccines, peptides, and dendritic cells. The difficulties of conducting and evaluating such studies in a pediatric population are also described, and a strategy for cancer vaccine development is outlined.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalCancer Journal
Volume11
Issue number4
DOIs
StatePublished - Jul 1 2005

Keywords

  • Antigens
  • Immune suppression
  • Leukemia
  • Neuroblastoma
  • Vaccine therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Vaccine therapies for pediatric malignancies'. Together they form a unique fingerprint.

Cite this