V1 neurons signal acquisition of an internal representation of stimulus location

Jitendra Sharma, Valentin Dragoi, Joshua B. Tenenbaum, Earl K. Miller, Mriganka Sur

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


A fundamental aspect of visuomotor behavior is deciding where to look or more next. Under certain conditions, the brain constructs an internal representation of stimulus location on the basis of previous knowledge and uses it to move the eyes or to make other movements. Neuronal responses in primary visual cortex were modulated when such an internal representation was acquired: Responses to a stimulus were affected progressively by sequential presentation of the stimulus at one location but not when the location was varied randomly. Responses of individual neurons were spatially tuned for gaze direction and tracked the Bayesian probability of stimulus appearance. We propose that the representation arises in a distributed cortical network and is associated with systematic changes in response selectivity and dynamics at the earliest stages of cortical visual processing.

Original languageEnglish (US)
Pages (from-to)1758-1763
Number of pages6
Issue number5626
StatePublished - Jun 13 2003

ASJC Scopus subject areas

  • General


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