Utilizing TH9 cells as a novel therapeutic strategy for malignancies

Yong Lu; Qing Yi

doi:10.4161/onci.23084

Utilizing T_H9 cells as a novel therapeutic strategy for malignancies

Yong Lu, Qing Yi

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

T_H9 cells join the ever-growing list of CD4⁺ T helper subsets and primarily mediate anti-parasite immune responses. We have recently demonstrated that tumor-specific T_H9 cells induce a CCL20-CCR6-dependent regulation of DCs while stimulating CD8⁺ T cell-mediated antitumor immunity. These findings offer a novel immunotherapeutic strategy against cancer.

Original language	English (US)
Article number	e23084
Journal	OncoImmunology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/onci.23084
State	Published - Mar 2013

Keywords

Ccl20
DCs
Melanoma
TCLs
Th9 cell

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

Access to Document

10.4161/onci.23084

Cite this

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title = "Utilizing TH9 cells as a novel therapeutic strategy for malignancies",

abstract = "TH9 cells join the ever-growing list of CD4+ T helper subsets and primarily mediate anti-parasite immune responses. We have recently demonstrated that tumor-specific TH9 cells induce a CCL20-CCR6-dependent regulation of DCs while stimulating CD8+ T cell-mediated antitumor immunity. These findings offer a novel immunotherapeutic strategy against cancer.",

keywords = "Ccl20, DCs, Melanoma, TCLs, Th9 cell",

author = "Yong Lu and Qing Yi",

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AU - Yi, Qing

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AB - TH9 cells join the ever-growing list of CD4+ T helper subsets and primarily mediate anti-parasite immune responses. We have recently demonstrated that tumor-specific TH9 cells induce a CCL20-CCR6-dependent regulation of DCs while stimulating CD8+ T cell-mediated antitumor immunity. These findings offer a novel immunotherapeutic strategy against cancer.

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KW - DCs

KW - Melanoma

KW - TCLs

KW - Th9 cell

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