Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma

Minying Cai; Zhonglin Liu; Hongchang Qu; Helen Fan; Zhiping Zheng; Victor J. Hruby

doi:10.1016/j.ejphar.2011.01.032

Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma

Minying Cai, Zhonglin Liu, Hongchang Qu, Helen Fan, Zhiping Zheng, Victor J. Hruby

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Peptides serve as effective drugs and contrast agents in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this we have been developing new methods to create 'tailor-made' peptides and peptide mimetics with improved pharmacological and physical properties. In this work we introduce novel peptide and small molecule conjugated molecules for earlier diagnosis and treatment of melanoma.

Original language	English (US)
Pages (from-to)	188-193
Number of pages	6
Journal	European Journal of Pharmacology
Volume	660
Issue number	1
DOIs	https://doi.org/10.1016/j.ejphar.2011.01.032
State	Published - Jun 11 2011

Keywords

Human melanocortin receptors
Melanoma
Melanotropin
MTII
Selective ligands for MC receptors
THIQ

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2011.01.032

Cite this

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title = "Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma",

abstract = "Peptides serve as effective drugs and contrast agents in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this we have been developing new methods to create 'tailor-made' peptides and peptide mimetics with improved pharmacological and physical properties. In this work we introduce novel peptide and small molecule conjugated molecules for earlier diagnosis and treatment of melanoma.",

keywords = "Human melanocortin receptors, Melanoma, Melanotropin, MTII, Selective ligands for MC receptors, THIQ",

author = "Minying Cai and Zhonglin Liu and Hongchang Qu and Helen Fan and Zhiping Zheng and Hruby, {Victor J.}",

year = "2011",

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T1 - Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma

AU - Cai, Minying

AU - Liu, Zhonglin

AU - Qu, Hongchang

AU - Fan, Helen

AU - Zheng, Zhiping

AU - Hruby, Victor J.

PY - 2011/6/11

Y1 - 2011/6/11

N2 - Peptides serve as effective drugs and contrast agents in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this we have been developing new methods to create 'tailor-made' peptides and peptide mimetics with improved pharmacological and physical properties. In this work we introduce novel peptide and small molecule conjugated molecules for earlier diagnosis and treatment of melanoma.

AB - Peptides serve as effective drugs and contrast agents in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this we have been developing new methods to create 'tailor-made' peptides and peptide mimetics with improved pharmacological and physical properties. In this work we introduce novel peptide and small molecule conjugated molecules for earlier diagnosis and treatment of melanoma.

KW - Human melanocortin receptors

KW - Melanoma

KW - Melanotropin

KW - MTII

KW - Selective ligands for MC receptors

KW - THIQ

UR - http://www.scopus.com/inward/record.url?scp=79955940728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955940728&partnerID=8YFLogxK

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DO - 10.1016/j.ejphar.2011.01.032

M3 - Review article

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AN - SCOPUS:79955940728

SN - 0014-2999

VL - 660

SP - 188

EP - 193

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma

Abstract

Keywords

ASJC Scopus subject areas

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