TY - JOUR
T1 - Utilization of targeted near-infrared molecular imaging to improve pulmonary metastasectomy of osteosarcomas
AU - Predina, Jarrod D.
AU - Newton, Andrew
AU - Deshpande, Charuhas
AU - Low, Philip
AU - Singhal, Sunil
N1 - Funding Information:
J.D.P. was supported by a grant from the American Philosophical Society, the NIH (F32 CA210409) and the Association for Academic Surgery Research Grant. S.S. was supported by the NIH (R01 CA193556).
Publisher Copyright:
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2018/1
Y1 - 2018/1
N2 - Pulmonary metastasectomy for osteosarcoma provides a select group of patients an opportunity for long-term survival and possible cure. Unfortunately, a complete metastasectomy is challenging due an inability to accurately identify lesions that lay below the threshold of preoperative imaging or intraoperative visual and tactile inspection. Growing evidence suggests that osteosarcomas express a number of unique molecular markers, including the folate receptor alpha. In this case report, we describe the application of a folate receptor-targeted, near-infrared optical contrast agent (OTL38) to improve osteosarcoma localization during minimally invasive pulmonary resection. In addition to localizing preoperatively identified lesions, this technology helped identify additional disease that was undetected on preoperative imaging or with traditional intraoperative techniques. This report marks the first successful utilization of a molecular imaging probe useful for osteosarcomas. This technology may provide a unique approach to improve pulmonary metastasectomy of osteosarcomas.
AB - Pulmonary metastasectomy for osteosarcoma provides a select group of patients an opportunity for long-term survival and possible cure. Unfortunately, a complete metastasectomy is challenging due an inability to accurately identify lesions that lay below the threshold of preoperative imaging or intraoperative visual and tactile inspection. Growing evidence suggests that osteosarcomas express a number of unique molecular markers, including the folate receptor alpha. In this case report, we describe the application of a folate receptor-targeted, near-infrared optical contrast agent (OTL38) to improve osteosarcoma localization during minimally invasive pulmonary resection. In addition to localizing preoperatively identified lesions, this technology helped identify additional disease that was undetected on preoperative imaging or with traditional intraoperative techniques. This report marks the first successful utilization of a molecular imaging probe useful for osteosarcomas. This technology may provide a unique approach to improve pulmonary metastasectomy of osteosarcomas.
KW - folate receptor alpha
KW - intraoperative imaging
KW - osteosarcoma
KW - surgery
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U2 - 10.1117/1.JBO.23.1.016005
DO - 10.1117/1.JBO.23.1.016005
M3 - Article
C2 - 29302953
AN - SCOPUS:85040311578
VL - 23
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 1
M1 - 016005
ER -