Utilization and outcomes of metastasectomy for patients with metastatic urothelial cancer: An analysis of the national cancer database

Furkan Dursun, Alexander Mackay, Jonathan C A Guzman, Evan Wenker, Zachary Klaassen, Padraic O'Malley, Bimal Bhindi, Cinthya Obando Perez, Jiaqiong Xu, Taehyun Roh, Guru Sonpavade, Christopher J D Wallis, Raj Satkunasivam

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: Surgical resection of oligometastatic disease has been shown to be associated with an improved survival in other malignancies, though its role is not established in metastatic urothelial carcinoma (mUC). We sought to examine utilization trends of metastasectomy in mUC and associated outcomes using the NCDB database. Methods: We queried the NCDB from 2004 to 2016 for patients with metastatic urothelial carcinoma who had undergone metastasectomy. The annual utilization trend of metastasectomy was evaluated by linear regression. We compared overall survival (OS) between propensity score matched patients who had undergone metastasectomy and those who had not using two-sided log-rank and Cox regression models. We also performed sensitivity analyses on subcohorts of mUC. Results: The utilization rate of metastasectomy in mUC was 7% and did not change significantly over time. Patients who received metastasectomy on average were younger, had >cT3 disease, had radical surgery to the primary tumor, and received systemic therapy. After propensity score matching, metastasectomy was not associated with an OS benefit for mUC patients (HR, 0.94; 95% CI, 0.83 to 1.07; P=0.38). Stratified subgroup analysis based on systemic therapy, radical surgery to primary tumor, clinical N stage, and primary location of disease did not show an OS benefit of metastasectomy. Conclusion: Metastasectomy is uncommonly used, though utilization has persisted over more than a decade. Despite selection biases and residual confounding favoring patients undergoing metastasectomy, we found similar OS among these individuals and those who did not undergo metastasectomy.

Original languageEnglish (US)
Pages (from-to)61.e21-61.e28
JournalUrologic Oncology: Seminars and Original Investigations
Issue number2
Early online dateAug 1 2021
StateE-pub ahead of print - Aug 1 2021


  • Bladder
  • Metastasectomy
  • Survival
  • Upper tract
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology


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