Using haplotype analysis to elucidate significant associations between genes and Hodgkin lymphoma

Anthony M. D'Amelio, Claudia Monroy, Randa El-Zein, Carol J. Etzel

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

In this study, we estimated the association between the inferred haplotypes in the inflammation, DNA repair, and folate pathways, and developed risk models for Hodgkin lymphoma. The study population consisted of 200 Hodgkin lymphoma cases and 220 controls. A susceptible association was observed on the XPC gene with haplotype CT (rs2228001 and rs2228000), and a protective association was observed on the IL4R gene with haplotype TCA (rs1805012, rs1805015, and rs1801275). These results can provide the necessary tools to identify high-risk individuals after validation in large data sets.

Original languageEnglish (US)
Pages (from-to)1359-1364
Number of pages6
JournalLeukemia Research
Volume36
Issue number11
DOIs
StatePublished - Nov 2012

Keywords

  • DNA repair
  • Haplotypes
  • Hodgkin lymphoma
  • Inflammation
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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