Use of T2MR in invasive candidiasis with and without candidemia

Ioannis M. Zacharioudakis; Fainareti N. Zervou; Eleftherios Mylonakis

doi:10.2217/fmb-2018-0079

Use of T2MR in invasive candidiasis with and without candidemia

Ioannis M. Zacharioudakis, Fainareti N. Zervou, Eleftherios Mylonakis

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The mortality associated with invasive candidiasis remains unacceptably high. The T2 magnetic resonance (T2MR) assay is a novel US FDA-Approved molecular diagnostic assay for the diagnosis of candidemia that can rapidly detect the five most commonly isolated Candida spp. In clinical trials, T2MR has exhibited good clinical sensitivity and specificity. Potential benefits from the adoption of T2MR technology in the diagnostic and therapeutic algorithms for invasive candidiasis can arise from timely diagnosis of disease, increased case detection, tailored therapy and decrease in empiric antifungal treatment. As everyday clinical experience with the assay is evolving, we discuss the utility of T2MR in invasive candidiasis with and without candidemia based on the currently available evidence regarding its performance.

Original language	English (US)
Pages (from-to)	1165-1173
Number of pages	9
Journal	Future Microbiology
Volume	13
Issue number	10
DOIs	https://doi.org/10.2217/fmb-2018-0079
State	Published - Aug 2018

Keywords

T2Candida
T2MR
abdominal candidiasis
candidemia
chronic disseminated candidiasis
invasive candidiasis

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

Access to Document

10.2217/fmb-2018-0079

Cite this

@article{e59e2fffa8a24668924d186a664b7195,

title = "Use of T2MR in invasive candidiasis with and without candidemia",

abstract = "The mortality associated with invasive candidiasis remains unacceptably high. The T2 magnetic resonance (T2MR) assay is a novel US FDA-Approved molecular diagnostic assay for the diagnosis of candidemia that can rapidly detect the five most commonly isolated Candida spp. In clinical trials, T2MR has exhibited good clinical sensitivity and specificity. Potential benefits from the adoption of T2MR technology in the diagnostic and therapeutic algorithms for invasive candidiasis can arise from timely diagnosis of disease, increased case detection, tailored therapy and decrease in empiric antifungal treatment. As everyday clinical experience with the assay is evolving, we discuss the utility of T2MR in invasive candidiasis with and without candidemia based on the currently available evidence regarding its performance.",

keywords = "T2Candida, T2MR, abdominal candidiasis, candidemia, chronic disseminated candidiasis, invasive candidiasis",

author = "Zacharioudakis, {Ioannis M.} and Zervou, {Fainareti N.} and Eleftherios Mylonakis",

note = "Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

month = aug,

doi = "10.2217/fmb-2018-0079",

language = "English (US)",

volume = "13",

pages = "1165--1173",

journal = "Future Microbiology",

issn = "1746-0913",

publisher = "Taylor and Francis Ltd.",

number = "10",

}

TY - JOUR

T1 - Use of T2MR in invasive candidiasis with and without candidemia

AU - Zacharioudakis, Ioannis M.

AU - Zervou, Fainareti N.

AU - Mylonakis, Eleftherios

PY - 2018/8

Y1 - 2018/8

N2 - The mortality associated with invasive candidiasis remains unacceptably high. The T2 magnetic resonance (T2MR) assay is a novel US FDA-Approved molecular diagnostic assay for the diagnosis of candidemia that can rapidly detect the five most commonly isolated Candida spp. In clinical trials, T2MR has exhibited good clinical sensitivity and specificity. Potential benefits from the adoption of T2MR technology in the diagnostic and therapeutic algorithms for invasive candidiasis can arise from timely diagnosis of disease, increased case detection, tailored therapy and decrease in empiric antifungal treatment. As everyday clinical experience with the assay is evolving, we discuss the utility of T2MR in invasive candidiasis with and without candidemia based on the currently available evidence regarding its performance.

AB - The mortality associated with invasive candidiasis remains unacceptably high. The T2 magnetic resonance (T2MR) assay is a novel US FDA-Approved molecular diagnostic assay for the diagnosis of candidemia that can rapidly detect the five most commonly isolated Candida spp. In clinical trials, T2MR has exhibited good clinical sensitivity and specificity. Potential benefits from the adoption of T2MR technology in the diagnostic and therapeutic algorithms for invasive candidiasis can arise from timely diagnosis of disease, increased case detection, tailored therapy and decrease in empiric antifungal treatment. As everyday clinical experience with the assay is evolving, we discuss the utility of T2MR in invasive candidiasis with and without candidemia based on the currently available evidence regarding its performance.

KW - T2Candida

KW - T2MR

KW - abdominal candidiasis

KW - candidemia

KW - chronic disseminated candidiasis

KW - invasive candidiasis

UR - http://www.scopus.com/inward/record.url?scp=85053277118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053277118&partnerID=8YFLogxK

U2 - 10.2217/fmb-2018-0079

DO - 10.2217/fmb-2018-0079

M3 - Review article

C2 - 29792512

AN - SCOPUS:85053277118

SN - 1746-0913

VL - 13

SP - 1165

EP - 1173

JO - Future Microbiology

JF - Future Microbiology

IS - 10

ER -

Use of T2MR in invasive candidiasis with and without candidemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this