Use of string test and stool specimens to diagnose pulmonary tuberculosis

Andrew R. DiNardo; Andrew Hahn; Jacinta Leyden; Charles Stager; Ellen Jo Baron; Edward A. Graviss; Anna M. Mandalakas; Elizabeth Guy

doi:10.1016/j.ijid.2015.10.022

Use of string test and stool specimens to diagnose pulmonary tuberculosis

Andrew R. DiNardo, Andrew Hahn, Jacinta Leyden, Charles Stager, Ellen Jo Baron, Edward A. Graviss, Anna M. Mandalakas, Elizabeth Guy

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10-85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum.

METHODS: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied.

RESULTS: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB.

CONCLUSION: The string test and stool provide diagnostic specimens that warrant further investigation.

Original language	English (US)
Pages (from-to)	50-52
Number of pages	3
Journal	International Journal of Infectious Diseases
Volume	41
DOIs	https://doi.org/10.1016/j.ijid.2015.10.022
State	Published - Dec 1 2015

Keywords

Stool
String test
Tuberculosis
Xpert MTB/RIF

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.ijid.2015.10.022

Cite this

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title = "Use of string test and stool specimens to diagnose pulmonary tuberculosis",

abstract = "BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10-85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum.METHODS: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied.RESULTS: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB.CONCLUSION: The string test and stool provide diagnostic specimens that warrant further investigation.",

keywords = "Stool, String test, Tuberculosis, Xpert MTB/RIF",

author = "DiNardo, {Andrew R.} and Andrew Hahn and Jacinta Leyden and Charles Stager and Baron, {Ellen Jo} and Graviss, {Edward A.} and Mandalakas, {Anna M.} and Elizabeth Guy",

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doi = "10.1016/j.ijid.2015.10.022",

language = "English (US)",

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journal = "International Journal of Infectious Diseases",

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publisher = "Elsevier",

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T1 - Use of string test and stool specimens to diagnose pulmonary tuberculosis

AU - DiNardo, Andrew R.

AU - Hahn, Andrew

AU - Leyden, Jacinta

AU - Stager, Charles

AU - Baron, Ellen Jo

AU - Graviss, Edward A.

AU - Mandalakas, Anna M.

AU - Guy, Elizabeth

PY - 2015/12/1

Y1 - 2015/12/1

N2 - BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10-85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum.METHODS: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied.RESULTS: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB.CONCLUSION: The string test and stool provide diagnostic specimens that warrant further investigation.

AB - BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10-85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum.METHODS: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied.RESULTS: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB.CONCLUSION: The string test and stool provide diagnostic specimens that warrant further investigation.

KW - Stool

KW - String test

KW - Tuberculosis

KW - Xpert MTB/RIF

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JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

ER -

Use of string test and stool specimens to diagnose pulmonary tuberculosis

Abstract

Keywords

ASJC Scopus subject areas

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