Use of string test and stool specimens to diagnose pulmonary tuberculosis

Andrew R. DiNardo, Andrew Hahn, Jacinta Leyden, Charles Stager, Ellen Jo Baron, Edward A. Graviss, Anna M. Mandalakas, Elizabeth Guy

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10-85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum.

METHODS: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied.

RESULTS: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB.

CONCLUSION: The string test and stool provide diagnostic specimens that warrant further investigation.

Original languageEnglish (US)
Pages (from-to)50-52
Number of pages3
JournalInternational Journal of Infectious Diseases
Volume41
DOIs
StatePublished - Dec 1 2015

Keywords

  • Stool
  • String test
  • Tuberculosis
  • Xpert MTB/RIF

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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