Use of stem cells in heart failure treatment: where we stand and where we are going

Luis A. Sánchez, Carlos E.nrique Guerrero-Beltrán, Andrea M. Cordero-Reyes, Gerardo García-Rivas, Guillermo Torre-Amione

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

End-stage heart failure is the final common pathway of an irreversible process associated with loss of myocardial cells. In this process, the capacity for renewal and repair of myocardial tissue is inadequate and ultimately leads to ventricular remodeling. Novel therapeutic strategies have been developed to prevent it, one being cell therapy, which has emerged as a potential approach to directly repopulate and repair the damaged heart. Here, we review the use of regenerative cell therapy for different cardiac diseases and discuss the positive effect of cell therapy mediated by paracrine factors instead of turning directly into cardiomyocytes.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalMethodist DeBakey cardiovascular journal
Volume9
Issue number4
DOIs
StatePublished - 2013

Keywords

  • bone marrow-derived cell therapy
  • cardiac stem cell therapy
  • dilated cardiomyopathy
  • heart failure

ASJC Scopus subject areas

  • Medicine(all)

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