Use of immunoadsorbent columns for antiacetylcholine receptor antibody removal from plasma of myasthenia gravis patients

Carlo Antozzi; Renato Mantegazza; Dionisio Peluchetti; Fulvio Baggi; Paola Romagnoli; Maurizio Marconi; Angelo Vescoyv; Ferdinando Cornelio

doi:10.1016/0278-6222(88)90036-8

Use of immunoadsorbent columns for antiacetylcholine receptor antibody removal from plasma of myasthenia gravis patients

Carlo Antozzi, Renato Mantegazza, Dionisio Peluchetti, Fulvio Baggi, Paola Romagnoli, Maurizio Marconi, Angelo Vescoyv, Ferdinando Cornelio

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The best apheretic approach to myasthenia gravis is the selective removal of antiacetylcholine receptor antibodies (antiAchR-Ab) from plasma. A new tryptophan-linked polyvinyl-alcohol gel recently reported to be able to adsorb IgG autoantibodies semiselectively from plasma was investigated in vitro. A consistent reduction of antiAchR-Ab ranging from 76% to 100% was observed in all plasma samples tested. Various degrees of reduction of other immunoglobulins were noted. The regeneration of the immunocolumn did not reduce the efficiency in autoantibody removal. Further in vitro and in vivo investigations are needed to confirm the clinical usefulness of this promising apheretic approach to myasthenia gravis.

Original language	English (US)
Pages (from-to)	73-75
Number of pages	3
Journal	Plasma Therapy and Transfusion Technology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0278-6222(88)90036-8
State	Published - 1988

ASJC Scopus subject areas

Immunology
Hematology

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title = "Use of immunoadsorbent columns for antiacetylcholine receptor antibody removal from plasma of myasthenia gravis patients",

abstract = "The best apheretic approach to myasthenia gravis is the selective removal of antiacetylcholine receptor antibodies (antiAchR-Ab) from plasma. A new tryptophan-linked polyvinyl-alcohol gel recently reported to be able to adsorb IgG autoantibodies semiselectively from plasma was investigated in vitro. A consistent reduction of antiAchR-Ab ranging from 76\% to 100\% was observed in all plasma samples tested. Various degrees of reduction of other immunoglobulins were noted. The regeneration of the immunocolumn did not reduce the efficiency in autoantibody removal. Further in vitro and in vivo investigations are needed to confirm the clinical usefulness of this promising apheretic approach to myasthenia gravis.",

author = "Carlo Antozzi and Renato Mantegazza and Dionisio Peluchetti and Fulvio Baggi and Paola Romagnoli and Maurizio Marconi and Angelo Vescoyv and Ferdinando Cornelio",

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T1 - Use of immunoadsorbent columns for antiacetylcholine receptor antibody removal from plasma of myasthenia gravis patients

AU - Antozzi, Carlo

AU - Mantegazza, Renato

AU - Peluchetti, Dionisio

AU - Baggi, Fulvio

AU - Romagnoli, Paola

AU - Marconi, Maurizio

AU - Vescoyv, Angelo

AU - Cornelio, Ferdinando

PY - 1988

Y1 - 1988

N2 - The best apheretic approach to myasthenia gravis is the selective removal of antiacetylcholine receptor antibodies (antiAchR-Ab) from plasma. A new tryptophan-linked polyvinyl-alcohol gel recently reported to be able to adsorb IgG autoantibodies semiselectively from plasma was investigated in vitro. A consistent reduction of antiAchR-Ab ranging from 76% to 100% was observed in all plasma samples tested. Various degrees of reduction of other immunoglobulins were noted. The regeneration of the immunocolumn did not reduce the efficiency in autoantibody removal. Further in vitro and in vivo investigations are needed to confirm the clinical usefulness of this promising apheretic approach to myasthenia gravis.

AB - The best apheretic approach to myasthenia gravis is the selective removal of antiacetylcholine receptor antibodies (antiAchR-Ab) from plasma. A new tryptophan-linked polyvinyl-alcohol gel recently reported to be able to adsorb IgG autoantibodies semiselectively from plasma was investigated in vitro. A consistent reduction of antiAchR-Ab ranging from 76% to 100% was observed in all plasma samples tested. Various degrees of reduction of other immunoglobulins were noted. The regeneration of the immunocolumn did not reduce the efficiency in autoantibody removal. Further in vitro and in vivo investigations are needed to confirm the clinical usefulness of this promising apheretic approach to myasthenia gravis.

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Use of immunoadsorbent columns for antiacetylcholine receptor antibody removal from plasma of myasthenia gravis patients

Abstract

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