Use of external shock-wave lithotripsy and adjuvant ursodiol for treatment of radiolucent gallstones - A national multicenter study

David Burnett, Atilla Ertan, Ronald Jones, J. Patrick O'Leary, Robert Mackie, John E. Robinson, Gerald Salen, Leroy Stahlgren, David H. Van Thiel, Louis Vassy, Norton J. Greenberger, Alan F. Hofmann

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

A prospective multicenter trial was performed to evaluate the use of external shockwave lithotripsy (ESL) and adjuvant medical therapy for the treatment of gallstones. A Medstone STS lithotripter was used together with ursodiol. Two hundred twenty-three patients were treated under general anesthesia (75%) or with intravenous analgesia (25%). Initial treatments were on an inpatient basis, but as centers gained experience, outpatient treatments became more common. Stone fragmentation and clearance were greatest in patients with solitary gallstones <2 cm in diameter. In this group of patients, stone fragmentation occurred in 97% of patients, and the cumulative stone-free rates at three and six months were 54% and 90%, respectively. These results indicate that fragmentation of gallstones can be achieved by a dry shock-wave lithotripter and that stone clearance is induced more rapidly by external shock-wave lithotripsy and adjuvant ursodiol therapy than by ursodiol therapy alone.

Original languageEnglish (US)
Pages (from-to)1011-1015
Number of pages5
JournalDigestive Diseases and Sciences
Volume34
Issue number7
DOIs
StatePublished - Jul 1 1989

Keywords

  • external shock-wave lithotripsy
  • gallstones
  • multicenter trial

ASJC Scopus subject areas

  • Gastroenterology

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