Use of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein: The Cross Cohort Collaboration

Zhiqi Yao; Erfan Tasdighi; Zeina A. Dardari; John Erhabor; Kunal K. Jha; Ngozi Osuji; Tanuja Rajan; Ellen Boakye; Carlos J. Rodriguez; Joao A.C. Lima; Suzanne E. Judd; Theodore Feldman; Jonathan A. Fialkow; Ramachandran S. Vasan; Omar El Shahawy; Emelia J. Benjamin; Aruni Bhatnagar; Andrew P. DeFilippis; Khurram Nasir; Michael J. Blaha

doi:10.1016/j.ahj.2024.10.012

Use of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein: The Cross Cohort Collaboration

Zhiqi Yao, Erfan Tasdighi, Zeina A. Dardari, John Erhabor, Kunal K. Jha, Ngozi Osuji, Tanuja Rajan, Ellen Boakye, Carlos J. Rodriguez, Joao A.C. Lima, Suzanne E. Judd, Theodore Feldman, Jonathan A. Fialkow, Ramachandran S. Vasan, Omar El Shahawy, Emelia J. Benjamin, Aruni Bhatnagar, Andrew P. DeFilippis, Khurram Nasir, Michael J. Blaha

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This cross-sectional study included 18,797 participants from 6 longitudinal cohorts (CARDIA, FHS Gen III, HCHS/SOL, MESA, MiHeart, and REGARDS), and 5,806 of them had high-sensitivity C-reactive protein (hs-CRP) measurements. We found that exclusive electronic cigarette (EC) use was associated with significantly lower hs-CRP levels compared to exclusive combustible cigarette use, suggesting a potentially lower inflammatory burden. hs-CRP levels in dual users and former smokers currently using EC were comparable to those observed in exclusive cigarette smokers. Exclusive EC users showed no significant difference in hs-CRP levels compared to never cigarette smokers. These findings have important implications for tobacco regulation, public health, and clinical practice, highlighting the need for continued monitoring of potential EC-related health impacts.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	American Heart Journal
Volume	280
DOIs	https://doi.org/10.1016/j.ahj.2024.10.012
State	Published - Feb 2025

Keywords

Humans
C-Reactive Protein/analysis
Male
Female
Cross-Sectional Studies
Middle Aged
Electronic Nicotine Delivery Systems/statistics & numerical data
Adult
Vaping/blood
Cigarette Smoking/blood
Aged
Tobacco Products
Longitudinal Studies
Cohort Studies

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.ahj.2024.10.012

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Yao, Z., Tasdighi, E., Dardari, Z. A., Erhabor, J., Jha, K. K., Osuji, N., Rajan, T., Boakye, E., Rodriguez, C. J., Lima, J. A. C., Judd, S. E., Feldman, T., Fialkow, J. A., Vasan, R. S., El Shahawy, O., Benjamin, E. J., Bhatnagar, A., DeFilippis, A. P., Nasir, K., & Blaha, M. J. (2025). Use of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein: The Cross Cohort Collaboration. American Heart Journal, 280, 1-6. https://doi.org/10.1016/j.ahj.2024.10.012

Yao, Z, Tasdighi, E, Dardari, ZA, Erhabor, J, Jha, KK, Osuji, N, Rajan, T, Boakye, E, Rodriguez, CJ, Lima, JAC, Judd, SE, Feldman, T, Fialkow, JA, Vasan, RS, El Shahawy, O, Benjamin, EJ, Bhatnagar, A, DeFilippis, AP, Nasir, K & Blaha, MJ 2025, 'Use of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein: The Cross Cohort Collaboration', American Heart Journal, vol. 280, pp. 1-6. https://doi.org/10.1016/j.ahj.2024.10.012

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title = "Use of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein: The Cross Cohort Collaboration",

abstract = "This cross-sectional study included 18,797 participants from 6 longitudinal cohorts (CARDIA, FHS Gen III, HCHS/SOL, MESA, MiHeart, and REGARDS), and 5,806 of them had high-sensitivity C-reactive protein (hs-CRP) measurements. We found that exclusive electronic cigarette (EC) use was associated with significantly lower hs-CRP levels compared to exclusive combustible cigarette use, suggesting a potentially lower inflammatory burden. hs-CRP levels in dual users and former smokers currently using EC were comparable to those observed in exclusive cigarette smokers. Exclusive EC users showed no significant difference in hs-CRP levels compared to never cigarette smokers. These findings have important implications for tobacco regulation, public health, and clinical practice, highlighting the need for continued monitoring of potential EC-related health impacts.",

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author = "Zhiqi Yao and Erfan Tasdighi and Dardari, \{Zeina A.\} and John Erhabor and Jha, \{Kunal K.\} and Ngozi Osuji and Tanuja Rajan and Ellen Boakye and Rodriguez, \{Carlos J.\} and Lima, \{Joao A.C.\} and Judd, \{Suzanne E.\} and Theodore Feldman and Fialkow, \{Jonathan A.\} and Vasan, \{Ramachandran S.\} and \{El Shahawy\}, Omar and Benjamin, \{Emelia J.\} and Aruni Bhatnagar and DeFilippis, \{Andrew P.\} and Khurram Nasir and Blaha, \{Michael J.\}",

year = "2025",

month = feb,

doi = "10.1016/j.ahj.2024.10.012",

language = "English (US)",

volume = "280",

pages = "1--6",

journal = "American Heart Journal",

issn = "0002-8703",

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T1 - Use of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein

T2 - The Cross Cohort Collaboration

AU - Yao, Zhiqi

AU - Tasdighi, Erfan

AU - Dardari, Zeina A.

AU - Erhabor, John

AU - Jha, Kunal K.

AU - Osuji, Ngozi

AU - Rajan, Tanuja

AU - Boakye, Ellen

AU - Rodriguez, Carlos J.

AU - Lima, Joao A.C.

AU - Judd, Suzanne E.

AU - Feldman, Theodore

AU - Fialkow, Jonathan A.

AU - Vasan, Ramachandran S.

AU - El Shahawy, Omar

AU - Benjamin, Emelia J.

AU - Bhatnagar, Aruni

AU - DeFilippis, Andrew P.

AU - Nasir, Khurram

AU - Blaha, Michael J.

PY - 2025/2

Y1 - 2025/2

N2 - This cross-sectional study included 18,797 participants from 6 longitudinal cohorts (CARDIA, FHS Gen III, HCHS/SOL, MESA, MiHeart, and REGARDS), and 5,806 of them had high-sensitivity C-reactive protein (hs-CRP) measurements. We found that exclusive electronic cigarette (EC) use was associated with significantly lower hs-CRP levels compared to exclusive combustible cigarette use, suggesting a potentially lower inflammatory burden. hs-CRP levels in dual users and former smokers currently using EC were comparable to those observed in exclusive cigarette smokers. Exclusive EC users showed no significant difference in hs-CRP levels compared to never cigarette smokers. These findings have important implications for tobacco regulation, public health, and clinical practice, highlighting the need for continued monitoring of potential EC-related health impacts.

AB - This cross-sectional study included 18,797 participants from 6 longitudinal cohorts (CARDIA, FHS Gen III, HCHS/SOL, MESA, MiHeart, and REGARDS), and 5,806 of them had high-sensitivity C-reactive protein (hs-CRP) measurements. We found that exclusive electronic cigarette (EC) use was associated with significantly lower hs-CRP levels compared to exclusive combustible cigarette use, suggesting a potentially lower inflammatory burden. hs-CRP levels in dual users and former smokers currently using EC were comparable to those observed in exclusive cigarette smokers. Exclusive EC users showed no significant difference in hs-CRP levels compared to never cigarette smokers. These findings have important implications for tobacco regulation, public health, and clinical practice, highlighting the need for continued monitoring of potential EC-related health impacts.

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KW - C-Reactive Protein/analysis

KW - Male

KW - Female

KW - Cross-Sectional Studies

KW - Middle Aged

KW - Electronic Nicotine Delivery Systems/statistics & numerical data

KW - Adult

KW - Vaping/blood

KW - Cigarette Smoking/blood

KW - Aged

KW - Tobacco Products

KW - Longitudinal Studies

KW - Cohort Studies

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AN - SCOPUS:85209588237

SN - 0002-8703

VL - 280

SP - 1

EP - 6

JO - American Heart Journal

JF - American Heart Journal

ER -

Use of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein: The Cross Cohort Collaboration

Abstract

Keywords

ASJC Scopus subject areas

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