Use of a single CAR T cell and several bispecific adapters facilitates eradication of multiple antigenically different solid tumors

Yong Gu Lee, Isaac Marks, Madduri Srinivasarao, Ananda Kumar Kanduluru, Sakkarapalayam M. Mahalingam, Xin Liu, Haiyan Chu, Philip S. Low

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Most solid tumors are comprised of multiple clones that ically different solid tumors implanted concurrently in NSG express orthogonal antigens, suggesting that novel strategies mice. Based on these data, we suggest that a carefully designed must be developed in order to adapt chimeric antigen receptor cocktail of bispecific adapters in combination with antifluor-(CAR) T-cell therapies to treat heterogeneous solid tumors. escein CAR T cells can overcome tumor antigen escape Here, we utilized a cocktail of low-molecular-weight bispecific mechanisms that lead to disease recurrence following many adapters, each comprised of fluorescein linked to a different CAR T-cell therapies. tumor-specific ligand, to bridge between an antifluorescein CAR on the engineered T cell and a unique antigen on the Significance: A cocktail of tumor-targeted bispecific adapters cancer cell. This formation of an immunologic synapse greatly augments CAR T-cell therapies against heterogeneous between the CAR T cell and cancer cell enabled use of a single tumors, highlighting its potential for broader applicability antifluorescein CAR T cell to eradicate a diversity of antigen-against cancers where standard CAR T-cell therapy has failed.

Original languageEnglish (US)
Pages (from-to)387-396
Number of pages10
JournalCancer research
Volume79
Issue number2
DOIs
StatePublished - Jan 15 2019

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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