Urologic Outcomes of Children With Hemorrhagic Cystitis After Bone Marrow Transplant at a Single Institution

Jason K. Au, Christopher Graziano, Rodolfo A. Elizondo, Sheila Ryan, David R. Roth, Chester J. Koh, Edmond T. Gonzales, Duong T. Tu, Nicolette Janzen, Swati Naik, Abhishek Seth

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: To analyze clinical outcomes and the risk factors associated with genitourinary (GU) morbidity and mortality in children who present with hemorrhagic cystitis (HC) after bone marrow transplant (BMT). Methods: A retrospective chart review of patients with HC who had undergone BMT at a single pediatric hospital from 2008 to 2015 was conducted. Demographic data, severity of hematuria, HC management, and mortality were analyzed. Bivariate analysis and binary logistic regression were performed to identify risk factors. Results: Out of 43 patients who met inclusion criteria, 67.4% were male with a median age at BMT of 10.2 years (interquartile range 5.8-14.6). Percutaneous nephrostomy catheters were inserted in 5 patients for urinary diversion. All-cause mortality was 32.6% (N = 14). Intravesical retroviral therapy (P

Original languageEnglish (US)
JournalUrology
DOIs
StateAccepted/In press - Jun 17 2016

ASJC Scopus subject areas

  • Urology

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