Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children

Barry D. Fletcher; Helen E. Heslop; Sue C. Kaste; Sara Bodner

doi:10.1007/s002470050393

Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children

Barry D. Fletcher, Helen E. Heslop, Sue C. Kaste, Sara Bodner

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report three patients who developed severe supraglottic airway obstruction due to Epstein-Barr virus lymphoproliferative disease following allogeneic bone marrow transplantation. In addition to enlarged pharyngeal lymphoid tissue seen in all three patients, two had supraglottic airway narrowing and two developed pulmonary lymphoproliferative disease. They were treated with unmanipulated T cells or EBV-specific cytotoxic T lymphocytes. Life-threatening upper airway obstruction is a radiologically detectable complication of allogeneic bone marrow transplantation in children.

Original language	English (US)
Pages (from-to)	492-496
Number of pages	5
Journal	Pediatric Radiology
Volume	28
Issue number	7
DOIs	https://doi.org/10.1007/s002470050393
State	Published - Jul 1998

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Radiology Nuclear Medicine and imaging

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10.1007/s002470050393

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title = "Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children",

abstract = "We report three patients who developed severe supraglottic airway obstruction due to Epstein-Barr virus lymphoproliferative disease following allogeneic bone marrow transplantation. In addition to enlarged pharyngeal lymphoid tissue seen in all three patients, two had supraglottic airway narrowing and two developed pulmonary lymphoproliferative disease. They were treated with unmanipulated T cells or EBV-specific cytotoxic T lymphocytes. Life-threatening upper airway obstruction is a radiologically detectable complication of allogeneic bone marrow transplantation in children.",

author = "Fletcher, \{Barry D.\} and Heslop, \{Helen E.\} and Kaste, \{Sue C.\} and Sara Bodner",

note = "Funding Information: Acknowledgements We thank Sharon Naron, MPA, for editorial assistance. This work was supported in part by the National cancer Institute, Cancer Center Support (CORE) grant P30CA21765, and by the American Lebanese Syrian Associated Charities.",

year = "1998",

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T1 - Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children

AU - Fletcher, Barry D.

AU - Heslop, Helen E.

AU - Kaste, Sue C.

AU - Bodner, Sara

N1 - Funding Information: Acknowledgements We thank Sharon Naron, MPA, for editorial assistance. This work was supported in part by the National cancer Institute, Cancer Center Support (CORE) grant P30CA21765, and by the American Lebanese Syrian Associated Charities.

PY - 1998/7

Y1 - 1998/7

N2 - We report three patients who developed severe supraglottic airway obstruction due to Epstein-Barr virus lymphoproliferative disease following allogeneic bone marrow transplantation. In addition to enlarged pharyngeal lymphoid tissue seen in all three patients, two had supraglottic airway narrowing and two developed pulmonary lymphoproliferative disease. They were treated with unmanipulated T cells or EBV-specific cytotoxic T lymphocytes. Life-threatening upper airway obstruction is a radiologically detectable complication of allogeneic bone marrow transplantation in children.

AB - We report three patients who developed severe supraglottic airway obstruction due to Epstein-Barr virus lymphoproliferative disease following allogeneic bone marrow transplantation. In addition to enlarged pharyngeal lymphoid tissue seen in all three patients, two had supraglottic airway narrowing and two developed pulmonary lymphoproliferative disease. They were treated with unmanipulated T cells or EBV-specific cytotoxic T lymphocytes. Life-threatening upper airway obstruction is a radiologically detectable complication of allogeneic bone marrow transplantation in children.

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Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children

Abstract

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