Update on estrogen signaling

Zhang Weihua, Sandra Andersson, Guojun Cheng, Evan R. Simpson, Margaret Warner, Jan Åke Gustafsson

Research output: Contribution to journalArticlepeer-review

191 Scopus citations


Our understanding of estrogen signaling has undergone a true paradigm shift over recent years, following the discovery in 1995 of a second estrogen receptor, estrogen receptor β (ERβ). In many contexts ERβ appears to antagonize the actions of ERα (yin/yang relationship) although there also exist genes that are specifically regulated by one of the two receptors. Studies of ERβ knockout mice have shown that ERβ exerts important functions in the ovary, central nervous system, mammary gland, prostate gland, hematopoiesis, immune system, vessels and bone. The use of ERβ-specific ligands against certain forms of cancer represents one of the many pharmaceutical possibilities that have been created thanks to the discovery of ERβ.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalFEBS Letters
Issue number1
StatePublished - Jul 3 2003


  • Breast cancer
  • Central nervous system
  • Estrogen
  • Estrogen receptor
  • Prostate

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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