There has been considerable progress made in identifying oncogenic driver mutations in advanced lung cancer. The recognition that lung cancer is actually an umbrella classification that is comprised of multiple molecular subgroups has had a profound impact on how medical oncologists make treatment decisions. These mutations are clinically important as available targeted therapies can achieve significant responses and prolonged disease control. This review will summarize the current guidelines for biomarker testing and available therapeutic agents.
- Anaplastic lymphoma kinase (ALK)
- Epidermal growth factor receptor (EGFR)
- Tumor mutational burden
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine