Unveiling the Metabolic Diversity in Cancer: Quantifying Cancer Stem Cells and Bulk Cancer Cells Through FLIM Imaging and Computational Analysis

Vidhya Shree Ravi, Abigail J. Clevenger, Sam Morganti, Shreya Raghavan , Alex J. Walsh

Research output: Contribution to conferencePaperpeer-review

Abstract

This study tests the hypothesis that Fluorescence Lifetime Imaging Microscopy (FLIM) of the endogenous metabolic co-enzymes (nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD)) provides insights into the metabolic signatures of CSCs and bulk tumor cells. By identifying and quantifying metabolic differences, researchers can potentially develop tailored therapies that address both CSCs and bulk tumor cells, improving therapeutic outcomes and addressing the challenges posed by tumor heterogeneity.

Original languageEnglish (US)
StatePublished - 2024
Event2024 Clinical and Translational Biophotonics, Translational 2024 - Part of Optica Biophotonics Congress: Biomedical Optic - Fort Lauderdale, United States
Duration: Apr 7 2024Apr 10 2024

Conference

Conference2024 Clinical and Translational Biophotonics, Translational 2024 - Part of Optica Biophotonics Congress: Biomedical Optic
Country/TerritoryUnited States
CityFort Lauderdale
Period4/7/244/10/24

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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